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Stem Cells in Rapidly Evolving Active Multiple Sclerosis — STREAMS  

Multiple Sclerosis Clinical Trial

Official title:
Stem Cells in Rapidly Evolving Active Multiple Sclerosis

Clinical Trial Summary

This is a randomised, double-blind crossover study to study the effect of intravenous treatment with autologous (derived from the individuals themselves) mesenchymal stem cells (MSCs) in patients with multiple sclerosis (MS).

Clinical Trial Description

Current treatments for MS target the immune system and are not curative. There is much interest in MSCs as they have the potential to not only affect the immune system but may also promote repair. This study will use MSCs that are harvested from the bone marrow and grown for up to 52 days before being given back to the person from whom they were harvested. This avoids any chemotherapy so is therefore safer than other types of stem cells. In this crossover study, everyone will receive their own stem cells back but in half of the patients it will be delayed by 24 weeks.

The primary outcomes are to check that the procedure is safe and to measure any changes on the MRI at 24 weeks. Other more exploratory measures will try to assess effects on repair in the central nervous system (CNS). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01606215
Study type Interventional
Source Imperial College London
Contact
Status Completed
Phase Phase 1/Phase 2
Start date January 2013
Completion date August 2019
View Details
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