Multiple Sclerosis Clinical Trial
— CogniSEPOfficial title:
Early Cognitive Impairment in Multiple Sclerosis: a Multimodal MRI Study Evaluating the Relative Contribution of Cortical and White Matter Tract Injury
Verified date | May 2010 |
Source | Assistance Publique - Hôpitaux de Paris |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Observational |
Cognitive impairment is one of the symptoms of Multiple Sclerosis (MS), and it may occur
during the first years of the disease. It usually affects attention, information processing
speed and short term memory. To date, the mechanisms of this specific symptom remain unclear
(local or global inflammation, neurodegenerative processes).
Magnetic Resonance Imaging (MRI) can be useful to understand the pathophysiology of
cognitive impairment in MS. The investigators will combine conventional and non conventional
MRI sequences to determine the respective role of white matter and grey matter injury and
the cortical reorganization of neuronal networks.
Status | Completed |
Enrollment | 69 |
Est. completion date | December 2010 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Relapsing remitting Multiple Sclerosis patients - Age: 18-40 years - Evolving between 3 and 5 years - EDSS<5 Exclusion Criteria: - MRI exclusion criteria (metallic prothetic, pace maker etc) - Renal failure due to Gadolinium injection - Major depressive disorder |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
France | Pitie salpêtrière Hospital | PAris |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris | ARSEP (Association pour la Recherche sur la Sclerose en Plaques), JNLF (Journées de Neurologie de Langue Française) |
France,
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