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NCT01628276 Clinical Trial

Brain Functional Connectivity Changes Following Cognitive Rehabilitation in Multiple Sclerosis: an fMRI Study

MS (Multiple Sclerosis) Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01628276
Other study ID # MSRC-AE-DCM-1
Secondary ID
Status Completed
Phase N/A
First received June 20, 2012
Last updated September 11, 2014
Start date July 2012
Est. completion date October 2013

Study information
Verified date September 2014
Source Sina Hospital, Iran
Contact n/a
Is FDA regulated No
Health authority Iran: Ministry of Health
Study type Interventional

Clinical Trial Summary

This trial seeks to investigate brain network changes following cognitive rehabilitation in MS patients. The investigators hypothesize that rehabilitation interventions improve connectivity in the brain.Novel Magnetic Resonance Imaging technique is performed to investigate changes in brain plasticity.

Recruitment information / eligibility
Status Completed
Enrollment 45
Est. completion date October 2013
Est. primary completion date September 2013
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 54 Years
Eligibility Inclusion Criteria:

- Definitive MS diagnosis

- Right handedness

- EDSS 0-4

- No relapse in past 6 weeks

- Willing to consent and participate in the study

Exclusion Criteria:

- Pregnancy

- Left handedness

- Neurologic or psychiatric disorder other than MS

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor)

Related Conditions & MeSH terms

Intervention

Behavioral:
• Cog Rehab
Cognitive rehab for MS patients

Locations
Country Name City State
Iran, Islamic Republic of Sina Hospital Tehran

Sponsors (1)
Lead Sponsor Collaborator
Sina Hospital, Iran

Country where clinical trial is conducted

Iran, Islamic Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary functional connectivity Changes in correlation of brain activity in different regions of brain as assessed by Blood Oxygenation Level Dependent (BOLD) signal 0, 2nd, 4th Month No
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