Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients

MRSA Infection Clinical Trial

— MOSAR-04  

Official title:

An Interventional Study to Evaluate the Impact of Two Innovative Strategies in Preventing Nosocomial MRSA Infection in Surgical Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00685867
• Other study ID #: LSHP-CT-037940
• Secondary ID: LSHP-CT-037940
• Status: Completed
• Phase: N/A
• First received: May 27, 2008
• Last updated: August 20, 2012
• Start date: May 2008
• Est. completion date: December 2010

Study information

• Verified date: August 2012
• Source: University Hospital, Geneva
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Swissmedic
• Study type: Interventional

Clinical Trial Summary

The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, Greece and Israel).

The primary objective is to determine the effect of an early MRSA detection & decolonization & isolation strategy compared to an enhanced standard control strategy on healthcare-associated MRSA isolation rates among surgical patients at risk of MRSA carriage, who are hospitalized for at least 24 hours.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 126750
• Est. completion date: December 2010
• Est. primary completion date: December 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Surgical patients with LOS>24h

Exclusion Criteria:

• Surgical patients with LOS<24h

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Infection
• MRSA Infection
• Staphylococcal Infections

Intervention

Other:
• Rapid molecular MRSA test
PCR-based rapid screening for MRSA carriage

Behavioral:
• Hand hygiene promotion
Promotion and monitoring of hand hygiene, with special emphasis on alcohol-based hand rubs and feedback of hand hygiene compliance Standard precautions (e.g. use of gloves for contacts with wounds and body fluids) Isolation precautions according to the hospitals' capacity and strategy Additional basic infection control interventions (if necessary)

Locations

Country	Name	City	State
Switzerland	Geneva University Hospitals	Geneva

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital, Geneva	European Commission

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nosocomial MRSA isolation rate (expressed as the monthly rate of MRSA in clinical isolates divided by the number of susceptible patients per hundred)		Monthly	No
Secondary	Nosocomial MRSA infection rate (= number of nosocomial MRSA infections per 100 admissions)		Monthly	No