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Mood Disorders clinical trials

View clinical trials related to Mood Disorders.

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NCT ID: NCT00225459 Completed - Anxiety Disorder Clinical Trials

Does Spiritual/Religious Commitment Mediate the Relationship Between Mood Variability and Suicidal Ideation.

Start date: June 2005
Phase: N/A
Study type: Observational

The purpose of this study is to determine whether or not spiritual and/or religious commitment affects mood variability and thoughts of suicide. First we hypothesize that among patients with depressive symptoms, those who have higher religious/spiritual (R/S) commitment will have less suicidal ideation and less mood variability. Second, we hypothesize that higher mood variability will be associated with more suicidal ideation. Finally, dependent on the first two hypotheses, we propose that R/S commitment will mediate the relationship between mood variability and suicidal ideation.

NCT ID: NCT00221468 Completed - Mood Disorders Clinical Trials

A Study of Quetiapine for the Treatment of Mood Disorders in Adolescents

Start date: June 2003
Phase: Phase 3
Study type: Interventional

The purpose of this research study is to obtain preliminary data regarding the effectiveness, tolerability, and safety of quetiapine therapy for adolescents who have a mood disorder and have at least one parent with bipolar disorder (severe mood swings).

NCT ID: NCT00217932 Completed - Mood Disorders Clinical Trials

Effectiveness of Divalproex Sodium (Depakote) in Treating Children With Temper Outbursts and Severe Mood Swings

Start date: September 2000
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the effectiveness of divalproex sodium (Depakote) versus placebo in treating children with temper outbursts and severe mood disorders.

NCT ID: NCT00211250 Completed - Mood Disorder Clinical Trials

Comparing Compliance, Tolerability, Efficacy and Adverse Events in Bipolar Tients From Valproic Acid to Depakote ER

Start date: July 2005
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare compliance, tolerability, effectiveness, and side-effects in Bipolar I and II patients switching from Valproic Acid to Depakote ER.

NCT ID: NCT00206544 Completed - Bipolar Disorder Clinical Trials

Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women?

Start date: January 2004
Phase: Phase 2
Study type: Interventional

OBJECTIVE: To test the use of two adjunctive hormonal agents in a 28 day three-arm, double-blind, placebo-controlled study in the treatment of acute mania/hypomania. HYPOTHESIS: That women receiving adjunctive Tamoxifen or Progesterone will demonstrate a more rapid and more substantial decrease in manic symptoms over the course of the study than women receiving adjunctive placebo. STUDY POPULATION: Sixty females with a current diagnosis of Bipolar Affective Disorder or Schizoaffective disorder - Manic Phase, according to the operationalised criteria of the Diagnostic and Statistical Manual, 4th edition (DSM-IV) of the American Psychiatric Association. STUDY MEDICATION: Tamoxifen. One third of patients (twenty) will be randomized to receive adjunctive Tamoxifen at 40 mg/day for 28 days. The Tamoxifen will be administered within a plain capsule to maintain "blinding" of treatment arm. Progesterone. One third of patients (twenty) will be randomized to receive adjunctive oral Provera (progesterone) at 20 mg/day. The Progesterone will be administered within a plain capsule identical to that used with Tamoxifen. Placebo. The remaining one third of patients will be randomized to receive adjunctive placebo (inert substance). The placebo substance will be administered within a plain capsule identical to that used with Tamoxifen and Progesterone. STUDY EVALUATIONS: Data will be collected over a 28-day period for each patient. Visits will be performed at baseline, and then at weekly intervals. A total of five visits will be completed for each patient. The following evaluations will be performed: - Psychiatric evaluation to determine diagnosis. (Baseline visit only) - General clinical evaluation including medical history, current conditions and a non-invasive physical examination, body weight, vital signs. (Baseline visit only) - Medication history (baseline and evaluation visits). - Demographics (baseline visits only). - Completion of clinical rating scales; CARS-M, PANSS, MADRS, AIMS, Barnes Akathisia scale (BA), and Simpson-Angus scale (SA) (baseline and evaluation visits). A Menstrual Cycle Interview and a cognitive assessment (RBANS) will be performed at baseline and endpoint (day 28) visit. - Laboratory tests including; Serum levels of mood stabilizer, luteinizing hormone (LH), follicle-stimulating hormone (FSH), Estrogen, Progesterone, Prolactin, dehydroepiandrosterone (DHEA), Testosterone and protein kinase C(PKC) (baseline and evaluation visits). - Inclusion/exclusion checklist (baseline visit only). - Informed consent (baseline visit only).

NCT ID: NCT00202514 Completed - Alcoholism Clinical Trials

Placebo Controlled Trial of Depakote ER in Alcohol Dependent Patients With Mood and/or Anxiety Symptoms

Start date: September 2004
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to test the safety and effectiveness of an extended release form of a medication called divalproex sodium (Depakote ER) for the treatment of people with alcohol dependence who have mood and/or anxiety symptoms. This medication has helped reduce symptoms of acute alcohol withdrawal as well as stabilize mood symptoms in bipolar disorder and other mental health disorders. This study will test the hypothesis that divalproex sodium will help reduce mood and anxiety symptoms during early abstinence from alcohol and in turn reduce relapse and craving for alcohol.

NCT ID: NCT00199940 Completed - Schizophrenia Clinical Trials

Safety And Efficacy Study Of Ziprasidone In Pediatric Psychotic Illness

Start date: December 2003
Phase: Phase 4
Study type: Interventional

The purpose of this research is to determine if Ziprasidone is safe and effective for use in children and adolescents with a psychotic illness, and to determine of Ziprasidone treatment leads to weight changes in children.

NCT ID: NCT00192998 Recruiting - Alzheimer Disease Clinical Trials

The Serotonergic Transmitter System in Dementia and Affective Disorders

Start date: October 2003
Phase: N/A
Study type: Observational

The aim of this project is to examine the serotonergic transmitter system using functional imaging of the brain (positron emission tomography [PET]) to gain knowledge about early pathophysiological changes in Alzheimer's dementia and mood disorders.

NCT ID: NCT00186758 Completed - Clinical trials for Bipolar Affective Disorder

Transcranial Magnetic Stimulation in Bipolar Depression

TMS
Start date: July 2002
Phase: Phase 4
Study type: Interventional

To compare antidepressant efficacy of left or right to sham Repetitive Transcranial Magnetic Stimulation (rTMS) to determine if non-responders can become responders if treated on the other side of the hemisphere (rTMS)

NCT ID: NCT00178828 Completed - Depression Clinical Trials

Dynamic Measures of Neurochemistry in Mood Disorders

Start date: October 2002
Phase: Phase 4
Study type: Interventional

The purpose of this study is to understand changes in brain chemical signals when people take antidepressants called sertraline (Zoloft®) and bupropion (Wellbutrin SR, Zyban ®). Spinal fluid is used to measure chemical levels of dopamine, serotonin, and other chemicals thought to be involved in depression. The study has potential to help understand and treat depression.