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Clinical Trial Summary

Primary Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders caused by mutations in genes encoded by nuclear Deoxyribonucleic Acid (DNA) or by mutations and/or deletions in the mitochondrial DNA (mtDNA). While some mitochondrial disorders only affect a single organ (e.g., the eye in Leber hereditary optic neuropathy [LHON]), many involve multiple organs. Mitochondrial disorders may present at any age and a frequent feature is the increasing number of organs involved in the course of the disease. Minovia Therapeutics Ltd. ("Minovia") is a biotech company developing novel therapeutics based on its mitochondrial augmentation technology (MAT). MNV-201 is a cell therapy produced by MAT that consists of the participant's autologous CD34+ hematopoietic stem and progenitor cells (HSPCs) enriched with allogeneic placental-derived mitochondria, manufactured in Minovia's GMP facility.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06017869
Study type Interventional
Source Minovia Therapeutics Ltd.
Contact Lea Bensoussan, Msc
Phone + 972 586101291
Email lea@minoviatx.com
Status Recruiting
Phase Phase 1
Start date July 31, 2023
Completion date December 2027

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