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Mitochondria in HIV and Aging (MITO+) — (MITO+)  

Mitochondrial Diseases Clinical Trial

Official title:
Mitochondria in HIV and Aging (MITO+)

Clinical Trial Summary

Older adults with human immunodeficiency virus (HIV) and a long history of antiretroviral therapy have more mitochondrial dysfunction- the cells that help them make energy. This dysfunction in mitochondria may lead to symptoms of muscle fatigue, physical function impairment, and impaired exercise tolerance compared to HIV-uninfected controls of a similar age and body mass index (BMI). Furthermore, the investigators hypothesize that the older antiretroviral therapy (ART) of tenofovir disoproxil fumarate (TDF) is associated with greater impairment in mitochondrial function than the newer agent, tenofovir alafenamide (TAF).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03489421
Study type Observational
Source University of Colorado, Denver
Contact
Status Completed
Phase
Start date December 15, 2018
Completion date September 5, 2019
View Details
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