Cognitive Fitness for Depression in Older Adults

Mild Cognitive Impairment Clinical Trial

Official title: Cognitive Remediation of Cognitive Control in Late-Life Depression

Status Recruiting

Clinical Trial Summary

This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants. The investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (MRI).

Clinical Trial Description

Major depression in the elderly is both challenging to treat and detrimental to the cognitive functioning of patients. Major depression increases the probability of a later dementia diagnosis. By targeting cognitive processes in treatment, the investigators hope to both find a more effective means to manage major depression in older adults, but also demonstrate how top-down processes (e.g., Executive Control Network) may be driving depression and cognitive decline in older adults.

The investigators are recruiting older adults with and without mild cognitive impairment. All subjects must have at least mild depressive symptoms to be eligible to participate. Subjects will be randomly assigned to one of two different interventions.

Results of this study will help the investigators understand the mechanisms that contribute to depressed mood and cognitive change in older adults with late life depression. ;

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Depression
• Depression Mild
• Depressive Disorder
• Depressive Disorder, Major
• Mild Cognitive Impairment

• NCT number: NCT04790630
• Study type: Interventional
• Source: UConn Health
• Contact: Seyenah Lopez
• Phone: 860-679-6189
• Email: seylopez@uchc.edu
• Status: Recruiting
• Phase: N/A
• Start date: November 15, 2020
• Completion date: July 31, 2024