Rheumatoid Arthritis Clinical Trial
Official title:
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease. Specifically, we collect a spit and blood sample to conduct in vitro stimulations and measurements of selected parameters related to periodontitis to clarify obscure areas in the immunologic pathogenesis of this disease.
Periodontitis is a prevalent, multifactorial inflammatory disease characterized by the
interaction between microorganisms organized in biofilms on tooth surfaces and host immune
cells, leading to an inflammatory destruction of the tooth-supporting tissues and - if left
untreated - eventually tooth loss. Periodontitis affects up to 50% of the population in the
United States of America, and is classified in an aggressive and a chronic form depending on
genetic factors, age of onset, speed and severity of attachment loss.
The onset of periodontitis is caused by an immunologic imbalance between host immune cells
and residing microorganisms in subgingival pockets. The host immune cells are capable of
enhancing both a protective and a destructive inflammatory response towards the
microorganisms through the release of inflammatory mediators e.i. proinflammatory and
antiinflammatory cytokines.
The role of antibodies in periodontitis is also unclear. Some studies show an excessive
antibody level against bacteria associated with periodontitis e.g. Porphyromonas gingivalis
(P.g.).
In general, this study contributes to a profound understanding of the host immune cells role
in the onset and pathogenesis of periodontitis by comparing healthy versus diseased donors
immunologic responses toward pathogene and apathogene microorganisms and their genetic
background.
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