Microbiota in Acute Pancreatitis: Prospective Multicenter Study

Status Not yet recruiting

Clinical Trial Summary

The objective of the study is to classify and carry out a quantitative analysis of the different bacterial species present in the intestinal microbiota of patients with acute pancreatitis and determine if there are significant differences regarding healthy controls. At the same time, the investigators pretend to determine if there are differences according to the etiology and severity of the disease and if the disregulation is temporary or is maintained after one month of discharge.

To carry out this purpose, the investigators have designed a prospective and multicentre observational study where samples of feces and saliva of patients admitted for acute pancreatitis of different etiologies and severity will be analyzed.

Clinical Trial Description

The study of the human microbiota is gaining importance given its relationship with the homeostasis of the organism as well as with certain pathologies. Specifically in the case of acute and chronic pancreatitis, recent studies suggest the disregulation of the intestinal flora as a possible determinant in the development and evolution of the disease. If this hypothesis is confirmed, hygienic-dietetic measures, as well as the administration of antibiotics, probiotics or fecal transplantation, may have therapeutic implications.

The objective of the study is to classify and carry out a quantitative analysis of the different bacterial species present in the intestinal microbiota of patients with acute pancreatitis and determine if there are significant differences regarding healthy controls. At the same time, the investigators also intend to determine if there are differences according to the etiology and severity of the disease and if the disregulation is temporary or is maintained after one month of discharge.

To carry out this purpose, it has been designed a prospective and multicentre observational study where samples of feces and saliva of patients admitted for acute pancreatitis of different etiologies and severity will be analyzed . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04038554
Study type	Observational
Source	Corporacion Parc Tauli
Contact	MNieves García-Monforte, PhD
Phone	+34629362957
Email	neusgmonforte@gmail.com
Status	Not yet recruiting
Phase
Start date	May 1, 2020
Completion date	September 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05414994` - Assessment of the Ocular Microbiome in Health and Disease
Completed	`NCT04769882` - Er:YAG Laser Effects on Microbial Population in Conservative Dentistry	N/A
Completed	`NCT04766528` - Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity	N/A
Completed	`NCT03720314` - Microbiota Profiling in IBS
Completed	`NCT04122612` - Shaping Microbiome in the First 1,000 Days of Life
Not yet recruiting	`NCT05405634` - Microbiota in Chronic Anal Fissure and Its Association With Prognosis
Not yet recruiting	`NCT04895774` - Ex Vivo Study of the Mechanism of Action of Active Ingredients on the Intestinal Microbiota
Recruiting	`NCT05992688` - The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)	N/A
Recruiting	`NCT05502380` - Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery	Phase 3
Completed	`NCT05175833` - Oral Probiotics and Secondary Bacterial Pneumonia in Severe COVID-19	Phase 2
Recruiting	`NCT04836910` - Microbiome and Polycystic Ovaries
Recruiting	`NCT05603650` - Effects of Mouthrinses on the Microbiome of the Oral Cavity and GI Tract	N/A
Completed	`NCT04991818` - MSC - OneBiome UX Pilot Study	N/A
Completed	`NCT05575050` - Impact of Teeth Brushing in Ventilated COVID-19 Patients.	N/A
Completed	`NCT04374955` - The Effect of Probiotic Added to Maternal Diet on Infantile Colic and Intestinal Microbiota Content	N/A
Recruiting	`NCT04140747` - Transfer of Strictly Anaerobe Microbes From Mother to Child
Recruiting	`NCT04111471` - The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients	N/A
Suspended	`NCT03220282` - The Milk, Growth and Microbiota Study	N/A
Completed	`NCT03422562` - Probiotics and Intestinal Microbiome in Preterm Infants	Phase 3
Recruiting	`NCT05695196` - Feasibility and Safety Study of Parent-to-Child Nasal Microbiota Transplant	Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.