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Clinical Trial Summary

AT13387/0001 is a dose-finding study of an experimental anticancer agent. In accordance with the protocol increasing doses of AT13387 are given to patients with advanced cancer who do not have alternative treatment options. The preferred dose of AT13387 will be identified according to the side effects experienced at different dose levels.


Clinical Trial Description

Increasing doses of AT13387 will be administered to groups of 3 to 6 patients at each dose level. The pharmacokinetic profile of AT13387 following a one hour intravenous infusion will be determined and the effect of AT13387 on predefined biomarkers in blood plasma and circulating white blood cells will be established. Patients will be closely monitored for the development of side effects which would preclude further dose escalation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00878423
Study type Interventional
Source Astex Pharmaceuticals, Inc.
Contact
Status Completed
Phase Phase 1
Start date May 2008
Completion date March 2014

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