Metastatic Hepatocellular Carcinoma Clinical Trial
Official title:
A Pilot Study Evaluating Atezolizumab and Bevacizumab Plus ADI-PEG 20 in Patients With Locally Advanced / Metastatic Hepatocellular Carcinoma
To learn about the safety and tolerability of atezolizumab, bevacizumab, and ADI-PEG 20 when given in combination to patients with locally advanced or metastatic liver cancer
Primary Objectives: --To evaluate the safety and tolerability of treatment with atezolizumab and bevacizumab + ADI-PEG 20 in Patients with Locally Advanced/ Metastatic Hepatocellular Carcinoma. Secondary Objectives: --To assess the pathologic response rate including pathologic complete response (pCR) per RECIST and degree of necrosis (>50% in tumor volume) with atezolizumab and bevacizumab + ADI-PEG 20 in treatment-naïve locally advanced or metastatic HCC. Exploratory Objectives: --To assess the immunological/biomarker changes (pre- vs. post-treatment) in tumor tissues and peripheral blood in response to atezolizumab and bevacizumab + ADI-PEG 20 in HCC therapy and explore any potential association between these biomarker measures and antitumor response. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04401800 -
Preliminary Antitumor Activity, Safety and Tolerability of Tislelizumab in Combination With Lenvatinib for Hepatocellular Carcinoma
|
Phase 2 | |
| Completed |
NCT01754987 -
A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and Effective
|
Phase 1/Phase 2 | |
| Recruiting |
NCT00752063 -
Sorafenib With Capecitabine and Oxaliplatin for Advanced or Metastatic Hepatocellular Carcinoma
|
Phase 2 | |
| Terminated |
NCT03695250 -
BMS-986205 and Nivolumab as First or Second Line Therapy in Treating Patients With Liver Cancer
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT04514484 -
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV
|
Phase 1 | |
| Recruiting |
NCT05075993 -
Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT04828486 -
Futibatinib and Pembrolizumab for Treatment of Advanced or Metastatic FGF19 Positive BCLC Stage A, B, or C Liver Cancer
|
Phase 2 | |
| Recruiting |
NCT05168163 -
Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer
|
Phase 2 | |
| Completed |
NCT03893695 -
Combination of GT90001 and Nivolumab in Patients With Metastatic Hepatocellular Carcinoma(HCC)
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06427941 -
A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab, in Participants With Advanced or Metastatic Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT05269381 -
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT04175912 -
Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver
|
Phase 2 | |
| Withdrawn |
NCT04025567 -
Vancomycin in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLC) Oral
|
Phase 2 | |
| Recruiting |
NCT03937830 -
Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects With Hepatocellular Carcinoma or Biliary Tract Carcinoma
|
Phase 2 | |
| Not yet recruiting |
NCT06066138 -
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
|
Phase 1 | |
| Recruiting |
NCT05199285 -
A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab
|
Phase 2 | |
| Recruiting |
NCT05003895 -
GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)
|
Phase 1 | |
| Recruiting |
NCT04511455 -
Cabozantinib for Patients With Hepatocellular Carcinoma (HCC) Refractory to First Line Treatment
|
Phase 2 | |
| Recruiting |
NCT04221893 -
Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers
|
N/A | |
| Recruiting |
NCT05092373 -
Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax
|
Phase 1 |