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Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)

Metastatic Cancer Clinical Trial

Official title:
A Randomized Study of Two Dosing Regimens of Adagrasib in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation

Clinical Trial Summary

This study will evaluate the efficacy of two dosing regimens of adagrasib (600 mg BID versus 400 mg BID) in patients with NSCLC with KRAS G12C mutation.

Clinical Trial Description

849-021 is a phase 2 study of adagrasib monotherapy in which patients are randomized between two dosing regimens. The study will evaluate the efficacy of two dosing regimens of adagrasib (600 mg BID without regard to food versus 400 mg BID with food) in patients with NSCLC with KRAS G12C mutation and who have received prior treatment with a platinum-based regimen and immune checkpoint inhibitor therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05853575
Study type Interventional
Source Mirati Therapeutics Inc.
Contact Mirati Therapeutics
Phone 1-844-893-5530
Email miratistudylocator@emergingmd.com
Status Recruiting
Phase Phase 2
Start date February 1, 2024
Completion date September 2025
View Details
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