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Clinical Trial Summary

This study will evaluate safety, tolerability, drug levels, molecular effects and clinical activity of MRTX849 (adagrasib) in combination with BI 1701963 in patients with advanced solid tumors that have a KRAS G12C mutation.


Clinical Trial Description

This study will evaluate safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics and clinical activity of MRTX849 (adagrasib) in combination with BI 1701963 in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 is an orally available small molecule inhibitor of KRAS G12C and BI 1701963 is a SOS1 pan-KRAS inhibitor. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04975256
Study type Interventional
Source Mirati Therapeutics Inc.
Contact
Status Completed
Phase Phase 1
Start date August 12, 2021
Completion date November 15, 2022

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