Metastatic Cancer Clinical Trial
Official title:
Cryosurgical Destruction of Surgically Incurable Liver Tumors
RATIONALE: Cryosurgery kills cancer cells by freezing them during surgery.
PURPOSE: Phase I/II trial to study the effectiveness of cryosurgery in treating patients
with unresectable primary liver cancer or liver metastases.
OBJECTIVES: I. Assess the safety and efficacy of liquid nitrogen necrosis of liver lesions
using a commercially available intraoperative cryosurgical system, with placement of the
cryoprobe and subsequent monitoring by high-resolution ultrasound. II. Use this technique on
selected patients with surgically unresectable metastatic or primary liver cancer whose
disease appears confined to the liver and who are potentially curable if all tumor in the
liver can be destroyed. III. Quantitate the quality and duration of survival, identify
recurrence of hepatic malignant disease, and identify any morbidity from the procedure.
OUTLINE: Cryosurgery. Liquid nitrogen freezing of tumor using a cryoprobe placed and
maintained under ultrasound guidance.
PROJECTED ACCRUAL: 50 patients will be treated.
;
Primary Purpose: Treatment
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