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NOvel Immunotherapy Strategies for Advanced Triple Negative Breast Cancer (TNBC) Patients: TONIC-3 Trial — TONIC-3  

Metastatic Breast Cancer Clinical Trial

Official title:
NOvel Immunotherapy Strategies for Advanced Triple Negative Breast Cancer (TNBC) Patients: TONIC-3 Trial

Clinical Trial Summary

This is a single center, non-blinded, multi-cohort, non-comparative phase II trial to study the safety and efficacy of tiragolumab with atezolizumab and/or ipilimumab in advanced triple-negative breast cancer.

Clinical Trial Description

Programmed cell death protein 1 (PD1) -blockade is currently being approved for the neoadjuvant treatment of early TNBC as well as for first-line treatment in combination with chemotherapy for patients with Programmed cell death-ligand 1 (PD-L1) -positive TNBC with metastatic disease. However, response rates are modest, responses are not always durable and PD-L1 is a suboptimal biomarker to select patients for this regimen. Therefore, the overarching goal of this TONIC-3 study is to develop novel immunomodulatory strategies for patients with advanced TNBC making use state-of-the-art research tools to better understand the underlying cancer-immune interactions of this disease ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06342037
Study type Interventional
Source The Netherlands Cancer Institute
Contact Marleen Kok, MD
Phone +3120512
Email m.kok@nki.nl
Status Recruiting
Phase Phase 2
Start date June 12, 2024
Completion date April 1, 2030
View Details
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