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A Study of SHR6390 Combined With Famitinib in the Treatment of HR + / HER2- Advanced Breast Cancer.

Metastatic Breast Cancer Clinical Trial

Official title:
An Exploratory Study of CDK4/6 Inhibitor SHR6390 Combined With Famitinib in the Treatment of HR + / HER2- Advanced Breast Cancer.

Clinical Trial Summary

The study is being conducted to assess the efficacy and safety of SHR6390 combined with famitinib in the treatment of advanced or metastatic breast cancer that progress in 1-2 line endocrine therapy.

Clinical Trial Description

This is a single-center, single-arm, open-label, Simon's two-stage design, phase II clinical trial. The purpose of this study was to evaluate the efficacy and safety of SHR6390 combined with famitinib in the treatment of HR+/HER2 advanced or metastatic breast cancer patients who have progressed during or after 1-2 line endocrine therapy. Subjects will be treated until disease progression, toxicity is intolerable, informed consent is withdrawn, and investigators determine that medication must be discontinued. Drug efficacy and safety data will be collected. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04733417
Study type Interventional
Source Tianjin Medical University Cancer Institute and Hospital
Contact
Status Active, not recruiting
Phase Phase 2
Start date May 26, 2021
Completion date September 30, 2023
View Details
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