| Eligibility |
Inclusion Criteria:
- Written informed consent obtained from the subject prior to performing any
protocol-related procedures, including screening evaluations
- Pre or postmenopausal women with stage IV hormone receptor-positive breast cancer by
histological or cytological confirmation
- Age > 19 years at time of study entry
- Progression after one line of any systemic therapy (endocrine, targeted or
chemotherapy) in the metastatic setting
- 2.1 or more nonsynonymous mutations per megabase (Mb) by WES
- Subject who has biopsy-accessible tumor
- At least one measurable lesion by RECIST 1.1. Biopsied tumor may be counted a
measurable lesion if it is not excised
- Documented disease progression on the most recent therapy
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 ~ 1
- Life expectancy of > 12 weeks
- Adequate normal organ and marrow function as defined below:
1. Haemoglobin = 9.0 g/dL
2. Absolute neutrophil count (ANC) = 1.5 x 109/L (> 1500 per mm3)
3. Platelet count = 100 x 109/L (>100,000 per mm3)
4. Serum bilirubin = 1.5 x institutional upper limit of normal (ULN). This will not
apply to subjects with confirmed Gilbert's syndrome (persistent or recurrent
hyperbilirubinemia that is predominantly unconjugated in the absence of hemolysis
or hepatic pathology), who will be allowed only in consultation with their
physician.
5. AST (SGOT)/ALT (SGPT) = 2.5 x institutional upper limit of normal unless liver
metastases are present, in which case it must be = 5x ULN
6. Serum creatinine CL>40 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault
1976) or by 24-hour urine collection for determination of creatinine clearance: ?
Males: Creatinine CL (mL/min) = Weight (kg) x (140 - Age) 72 x serum creatinine
(mg/dL), ? Females: Creatinine CL (mL/min) = Weight (kg) x (140 - Age) x 0.85 72
x serum creatinine (mg/dL)
- Female subjects must either be of non-reproductive potential (ie, post-menopausal by
history: = 60 years old and no menses for 1 year without an alternative medical cause;
OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of
bilateral oophorectomy) or must have a negative serum pregnancy test upon study entry.
Otherwise, subjects must adhere to acceptable forms of birth control (a
physician-approved contraceptive method: oral, injectable, or implantable hormonal
contraceptive; intra-uterine device; barrier contraceptive with spermicide; or
vasectomized partner).
- Subject is willing and able to comply with the protocol for the duration of the study
including undergoing treatment and scheduled visits and examinations including follow
up.
Exclusion Criteria:
- Involvement in the planning and/or conduct of the study (applies to both AstraZeneca
staff and/or staff at the study site). Previous enrollment in the present study
- Participation in another clinical study with an investigational product during the
last 4 weeks
- Any previous treatment with a PD-1 or PD-L1 inhibitor, including durvalumab or an
anti-CTLA-4, including tremelimumab
- Previous or coexisting malignancies. However, malignancies that have been curatively
treated >5 years prior to study entry can be included. Exceptionally, cervical cancer
in-situ, basal cell carcinoma, papillary thyroid carcinoma and superficial bladder
tumors (T1a and Tis) can be included anytime after curative treatment
- Receipt of the last dose of anti-cancer therapy (chemotherapy, immunotherapy,
endocrine therapy, targeted therapy, biologic therapy, tumor embolization, monoclonal
antibodies, other investigational agent) = 21 days prior to the first dose of study
drug and within 6 weeks for nitrosourea or mitomycin C) for sufficient wash-out time
- Palliative radiation, whole brain radiotherapy (WBRT), or gamma knife surgery (GKS)
for brain metastases = 2 weeks prior to initiation of study medication. Major surgery
= 4 weeks or minor surgery = 2 weeks prior to initiation of study medication. Majority
or minority of surgery can be decided at the investigator's discretion. Subjects who
received these local therapy may be enrolled after predetermined time period
- Mean QT interval corrected for heart rate (QTc) =470 ms calculated from 3
electrocardiograms (ECGs) using Fredericia's Correction
- Current or prior use of immunosuppressive medication within 28 days before the first
dose of durvalumab or tremelimumab, with the exceptions of intranasal and inhaled
corticosteroids or systemic corticosteroids at physiological doses, which are not to
exceed 10 mg/day of prednisone, or an equivalent corticosteroid
- Any unresolved toxicity (=CTCAE grade 2) from previous anti-cancer therapy. Subjects
with irreversible toxicity that is not reasonably expected to be exacerbated by the
investigational product may be included (e.g., hearing loss, peripherally neuropathy)
- Any prior Grade =3 immune-related adverse event (irAE) while receiving any previous
immunotherapy agent, or any unresolved irAE >Grade 1
- Active or prior documented autoimmune disease within the past 2 years NOTE: Subjects
with vitiligo, Grave's disease, or psoriasis not requiring systemic treatment (within
the past 2 years) are not excluded.
- Active or prior documented inflammatory bowel disease (e.g., Crohn's disease,
ulcerative colitis)
- History of primary immunodeficiency
- History of allogeneic organ transplant
- History of hypersensitivity to durvalumab or tremelimumab
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis, active
bleeding diatheses including any subject known to have evidence of acute or chronic
hepatitis A (anti-HAV antibody+), hepatitis B (HBs antigen+), hepatitis C (anti-HCV
antibody+) or human immunodeficiency virus (HIV-1 or HIV-2 antibody+ or HTLV-1
antibody+), or psychiatric illness/social situations that would limit compliance with
study requirements or compromise the ability of the subject to give written informed
consent
- Known history of previous clinical diagnosis of tuberculosis
- Receipt of live attenuated vaccination within 30 days prior to study entry or within
30 days of receiving durvalumab or tremelimumab
- Any condition that, in the opinion of the investigator, would interfere with
evaluation of study treatment or interpretation of patient safety or study results
- Symptomatic brain metastasis or leptomeningeal seeding. However, after WBRT or GKS for
symptomatic brain or leptomeningeal metastases, if subjects are stable for 4 weeks
without steroid and the dosage of anti-convulsant is stable for 4 weeks, they are
eligible. Asymptomatic central nervous system metastases are eligible if the subject
has no abnormal findings on neurologic examination and is not receiving corticosteroid
therapy to control symptoms
- Subjects with uncontrolled seizures
- Female patients who are pregnant or breastfeeding or female subjects of reproductive
potential who are not willing to employ effective birth control from screening to 180
days after the last dose of durvalumab + tremelimumab combination therapy or 90 days
after the last dose of durvalumab monotherapy, whichever is the longer time period
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