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Patterns of Prescribing and Monitoring of Palbociclib

Metastatic Breast Cancer Clinical Trial

Official title:
Patterns of Prescribing and Monitoring of Palbociclib

Clinical Trial Summary

The purpose of this study is to determine if patients with ER+, human epidermal growth factor 2 negative (HER2-), advanced breast cancer are receiving dosing adjustments and monitoring based on manufacturer recommendations at a tertiary academic medical center.

Clinical Trial Description

This study was a retrospective, single-center study that included women receiving palbociclib for the treatment of ER+, HER2- advanced breast cancer. Exclusion criteria were the presence of brain metastases or active enrollment in a palbociclib clinical trial. The primary endpoint was the proportion of patients who were maintained on a palbociclib dose according to the adjustment schedule in package insert recommendations. The secondary endpoints were the number of patients dose adjusted for hematologic toxicities, the number of patients experiencing neutropenia, duration of therapy, progression-free survival (PFS), and adherence to manufacturer monitoring recommendations. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03285568
Study type Observational
Source Rush University Medical Center
Contact
Status Completed
Phase
Start date February 3, 2015
Completion date December 30, 2016
View Details
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