Metastatic Breast Cancer Clinical Trial
Official title:
HER2-PET as a Diagnostic Tool in Breast Cancer Patients With a Clinical Dilemma
Information about the presence of human epidermal growth factor receptor 2 (HER2) in tumor
lesions in breast cancer patients is essential for diagnostic and therapeutic management of
metastatic breast cancer. In daily practice however, obtaining a metastasis biopsy can be
difficult or impracticable. Therefore, clinicians can be faced with a persistent clinical
dilemma in some breast cancer patients, leading to suboptimal therapy decisions due to lack
of HER2 receptor information. Circulating tumor cells (CTCs), which may provide additional
information, have so far not been able to replace the biopsy. To solve this problem,
non-invasive whole body visualization and quantification of HER2 expression by means of the
HER2-PET may be a valuable tool.
In this prospective multicenter imaging study, eligible patients will receive one HER2-PET
and CTC analysis in addition to standard work up for metastatic disease. Subsequent
administration of anti-HER2 therapy will be evaluated. Referring physicians fill in three
questionnaires, one before HER2-PET and two after HER2-PET.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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