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Metabolic Bone Disease clinical trials

View clinical trials related to Metabolic Bone Disease.

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NCT ID: NCT06199102 Not yet recruiting - Clinical trials for Vitamin D Deficiency

The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants.

HIDVID
Start date: September 1, 2024
Phase: N/A
Study type: Interventional

The aim of this study will be to assess the effectiveness of monitored vit D supplementation in a population of preterm infants and to identify whether the proper vit D supplementation in preterm infants can reduce the incidence of neonatal sepsis and incidence of metabolic bone disease.

NCT ID: NCT05909228 Completed - Osteoporosis Clinical Trials

Bone Markers in Pediatric IF

Start date: March 31, 2023
Phase:
Study type: Observational

Poor bone health is a well-recognized but poorly understood complication in children with intestinal failure (IF) who are dependent on parenteral nutrition (PN). Previously, we showed that children with IF have decreased bone turnover markers. It is currently unknown if optimization of parenteral nutrition is related to improved bone turnover markers. Serum concentrations of bone markers (osteocalcin, bone-specific alkaline phosphatase and c-telopeptide) will be measured in 30 IF patients treated at a multidisciplinary intestinal rehabilitation and home PN program at the Hospital for Sick Children and compared to bone markers in 30 age- and sex-matched healthy controls.

NCT ID: NCT04752098 Enrolling by invitation - Osteopenia Clinical Trials

A Study to Assess Metabolic Bone Disease of Prematurity Using an Acoustic Method

Start date: September 2, 2020
Phase: N/A
Study type: Interventional

The goal of this project is to develop a new noninvasive ultrasound based technique, called vibro-acoustic analysis (VAA), for evaluation of infant bone health with particular application in assessment of bone health in premature infants who are at risk for bone disease.

NCT ID: NCT04356807 Completed - Clinical trials for Metabolic Bone Disease

Physical Therapy to Prevent Osteopenia in Preterm Infants

Start date: February 2016
Phase: N/A
Study type: Interventional

To determine whether reflex locomotion therapy is effective for the prevention of osteopenia in preterm infants and compare its effectiveness over other physiotherapeutic methods like passive joint mobilizations and massage

NCT ID: NCT03878134 Completed - Cancer Clinical Trials

Translational Development of Photon-counting CT Imaging

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

Using an investigational CT scanner which uses a new type of detector to capture X-rays, (a photon counting CT detector), the goal of this experimental study is to compare conventional CT images to CT images using the photon counting detector in patients undergoing CT scans for clinically indicated reasons. The main question it aims to answer is whether the images produced using the new detectors are superior in quality. Participants will undergo the clinically indicated CT images and the photon counting detector CT images of a limited area during the same examination time.

NCT ID: NCT03811873 Completed - Clinical trials for Transplant-Related Disorder

Assessment of Vertebral Fracture Risk for First Time Liver Transplant Candidates

VFA
Start date: February 18, 2019
Phase: N/A
Study type: Interventional

The researchers are trying to compare the effectiveness of Vertebral Fracture Assessment (VFA) in addition to the current standard of care spine x-ray in evaluation pre-liver transplant patients.

NCT ID: NCT03371199 Completed - Hyponatremia Clinical Trials

The Association Between Hyponatremia and Osteoporosis in Patients With Epilepsy.

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

The study investigates the association between normalization of serum sodium levels and bone markers in patients with epilepsy and chronic hyponatremia. The study is a randomized, single blinded, placebo controlled study where participants will be randomized to either treatment with salt tablets or placebo tablets through 4 months. At the beginning and end of the 4 months bone markers will be measured. The investigators null-hypothesis is that there will be no difference in bone markers before or after the intervention.

NCT ID: NCT02853539 Completed - Clinical trials for Metabolic Bone Disease

Denosumab in Metabolic Bone Disease in Chronic Intestinal Failure Patients

Denoz
Start date: January 2011
Phase: Phase 4
Study type: Interventional

Low bone mineral density (BMD) is commonly reported in patients receiving home parenteral nutrition (HPN). Denosumab represent a new drug, which helped to prevent osteoclast. The aim of the study was to assess its value in chronic intestinal failure patients.

NCT ID: NCT02843048 Active, not recruiting - Obesity Clinical Trials

Bariatric Surgery and Exercise Bone Trial

BaSEIB
Start date: April 2016
Phase: N/A
Study type: Interventional

Despite being effective in weight reduction in severely obese patients, bariatric surgery (BS) negatively influences bone metabolism and increases the risk of falls thereby potentially increasing the risk of fracture. The mechanisms of BS induced bone loss are unknown but may be related to calcium and vitamin D malabsorption, changes in the energy regulation metabolism and gastrointestinal hormonal physiology. Since the etiology of BS induced bone loss is largely unknown, treatment relies mostly on calcium and vitamin D supplementation, which provide little benefit. Exercise is an effective strategy to prevent bone mass losses in several health conditions. However, no study so far has examined the effects of an exercise-training program in the prevention of BS induced bone loss. The investigators main goal is to investigate the effects on bone metabolism and fracture risk of an exercise-training program specifically tailored to improve bone health and balance of patients that underwent BS. The investigators will perform a randomized controlled trial on obese patients (n=80; BMI>40 Kg.m-2) elected to BS. Patients will be randomly assigned into 2 groups i) a group receiving standard follow-up and medical care, or ii) a group that will undergo a 11 months' Exercise Training program designed to improve bone health and reduce fall risk plus the standard follow-up and medical care. All patients will be assessed i) before the surgery, ii) one month, iii) 6 months, and iv) 12 months after the surgery. Assessments include: biochemical markers of bone turnover (BTM), BMD, bone tissue biomechanical properties, hormones involved in the regulation of energy, gastrointestinal and bone metabolism, body composition, BMI, nutritional intake, balance, muscle strength, cardiorespiratory fitness and daily physical activity. These evaluations will allow the investigators to understand the effects of an exercise-training program on bone metabolism of BS patients, contributing also to further elucidate the mechanisms underlying BS induced bone loss and fracture risk increase. The investigators will use established methods in the literature as well as novel procedures, which will enable them to overcome some of the limitations of previous studies. At the end of the study the investigators expect to have collected consistent data about whether an exercise-training program is or is not able to effectively prevent BS induced bone losses and fracture risk increases.

NCT ID: NCT01603472 Completed - Clinical trials for Metabolic Bone Disease

Markers of Bone Disease in Children on Parenteral Nutrition

Start date: May 2012
Phase: N/A
Study type: Observational

Parenteral nutrition (PN) is the provision of nutrients via the intravenous route. Parenteral nutrition associated metabolic bone disease (MBD) was first described in children in the 1980s. Since then, there has been little to no research into the underlying relationship and as a result, little evidence on which to base clinical care. In adults, MBD is associated with increased fractures. At the Hospital for Sick children in Toronto, an intestinal failure program has been set up since 2003. This is the only intestinal failure program in Canada and receives country wide referrals. Most of the patients have short bowel syndrome (SBS) and require PN for prolonged periods, or for life. About 90% of these patients have MBD, and some have had bone fractures. An understanding of the etiology of MBD would provide information to guide care, and prevent this condition. Funding for this area of research however is challenging because intestinal failure requiring long term PN is a rare condition, accounting for approximately 200 - 300 children in all of Canada. The goal of this study therefore is to gather pilot data on markers of MBD in children on long term PN, and to compare these markers to age and gender matched control patients who are fed by mouth or feeding tube. The information gathered from this study will help us begin to understand what is actually happening in the bones of children on long term PN and will form the basis for future studies and improved clinical care.