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Evaluation of the Hemodynamic Effects of Transvenous Phrenic Stimulation — HEMOSTIM  

Mechanical Ventilation Clinical Trial

Official title:
Evaluation of the Hemodynamic Effects of Transvenous Phrenic Stimulation

Clinical Trial Summary

Mechanical ventilation is a cornerstone in the management of severe forms of pneumonia, acute respiratory distress syndrome. It provides essential oxygen to patients, ventilates the lungs but also has deleterious effects like any treatment, in particular by reducing cardiac output by reducing venous return. Mechanical ventilation also has effects on the diaphragm: diaphragmatic dysfunction. It is explained by a prolonged inactivity of this muscle with a reduction of muscle fibers that can settle down quickly, after only a few days of mechanical ventilation. This dysfunction results in a reduction in the latter's ability to generate intrathoracic pressure necessary for ventilation, slows the withdrawal of mechanical ventilation and lengthens the duration of stay in intensive care unit. To reduce this dysfunction, phrenic stimulation has been proposed as an alternative to remuscler the diaphragm thanks to electrodes located on a central venous catheter, also used to deliver the usual therapies in intensive care unit. The HEMOSTIM study is interested in the effects of phrenic stimulation on regional ventilation, cardiac output and cerebral perfusion: investigator hypothesize that diaphragmatic stimulation allows an improvement of these parameters.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04680351
Study type Interventional
Source University Hospital, Angers
Contact Marie LEMERLE
Phone 0241353637
Email marie.lemerle@chu-angers.fr
Status Not yet recruiting
Phase N/A
Start date March 1, 2021
Completion date April 1, 2023
View Details
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