Identification of Risk Factors for Alteration of the Cellular-arterial Gradient of CO2

Mechanical Ventilation Clinical Trial

— DELTA-CAPNO  

Official title:

DELTA-CAPNO: Identification of Risk Factors for Alteration of the Cellular-arterial Gradient of CO2 in Pre-hospital Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04489615
• Other study ID #: UH Angers
• Status: Recruiting
• Start date: June 3, 2020
• Est. completion date: June 1, 2021

Study information

• Verified date: November 2020
• Source: University Hospital, Angers
• Contact: Quentin qc Carraro, md
• Phone: 778817861
• Email: quentin.carrar[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Monocentric, prospective, observational and descriptive study on the evaluation of risk factors for alteration of the alveoarterial gradient of CO2 in pre-hospital patients, intubated and then ventilated in an invasive manner; and their impact on intra-arterial fatehospital.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: June 1, 2021
• Est. primary completion date: April 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• 18 years of age,

• Endotracheal intubation in pre-hospital and mechanical ventilation,

• Monitoring of Etco2 in pre-hospital settings

Exclusion Criteria:

• Identification of a chest wound blowing during pre-hospital care,

• No technical possibility for performing or analysing arterial sampling,

• Death during pre-hospital care,

• A person who has objected to the processing of his data for research at minimal risk and constraints (category 2) or for research on data, as well as persons subject to legal protection measures.

Related Conditions & MeSH terms

• Mechanical Ventilation
• Prehospital Capnography Monitoring

Locations

Country	Name	City	State
France	Quentin Carraro	Angers

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Angers

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	identification of risks factors for alteration of the cellular arterial gradient of CO2 in Pre hospital patients	The main objective is therefore to determine the main risk factors to observe an alteration of the alveoarterial gradient in CO2, at the hospital care (fixed at 10 mmHg).	from january 2020 to april 2021
Secondary	Intrahospital mortality	prognostic evidence of altered alveocapillary gradient on intrahospital mortality	from january 2020 to april 2021
Secondary	Time of hospital admission	the prognosis of the finding of an altered alveocapillary gradient on the time of hospital admission	from january 2020 to april 2021
Secondary	length of mecanical ventilation	the prognosis of the finding of an altered alveocapillary gradient on the duration of ventilation	from january 2020 to april 2021
Secondary	Occurence of pneumonia	the prognosis of the finding of an altered alveocapillary gradient on the occurrence of pneumonia	from january 2020 to april 2021
Secondary	Acute respiratory distress syndrom (ARDS)	the prognosis of the finding of an altered alveocapillary gradient on the occurrence of ARDS	from january 2020 to april 2021
Secondary	Length of stay	the prognosis of the finding of an altered alveocapillary gradient on the length of stay	from january 2020 to april 2021
Secondary	Intrahospital mortality (subpopulation of traumatized patients which had suffered from intracranial hypertension	prognostic evidence of altered alveocapillary gradient, onset of an episode of intracranial hypertension, and intrahospital survival of severely traumatized patients (GCS < 9).	from january 2020 to april 2021