Diaphragm Ultrasound Measurements With Variations in Modes of Ventilation

Status Active, not recruiting

Clinical Trial Summary

The overall objective of the study is to conduct an observational study involving intensive care unit patients receiving mechanical ventilation and determine if there are differences in diaphragm thickness ultrasound measurements during expiratory and inspiratory phases in a controlled and spontaneous mode. For patients receiving sedatives, an additional set of measurements will be taken during a standard of care interruption of sedatives

Clinical Trial Description

In this study diaphragm ultrasound measurements at end-expiration and peak inspiration phases in assist control and pressure support mode in consented patients admitted to the medical intensive care unit. One-time measurements will be obtained during the first 48hrs that the patients are receiving mechanical ventilation. In patients receiving sedatives, additional measurements will be taken after an interruption of sedatives. Measurements will be compared between modes and on assist-control before and after an interruption of sedatives. Three consecutive images will be obtained by an investigator that is blinded to the mode (controlled vs. spontaneous). Once measurements are obtained, a second investigator will switch to the other mode (controlled vs. spontaneous) and the blinded investigator will obtain three consecutive images after the patient has adjusted to the subsequent mode (one minute). Tidal volumes will be matched between modes as close as possible. The order of modes to ultrasound (controlled then spontaneous or spontaneous then controlled) will be determined by the non-blinded second investigator. Once the ultrasound measurements are obtained by the research team, image acquisition is concluded for the enrolled patient. The ventilator will be programmed back to the original settings determined by the medical ICU team. The hypothesis is that the end-expiration diaphragm ultrasound measurement will be thicker in spontaneous mode than controlled mode. ;

Study Design

Related Conditions & MeSH terms

Mechanical Ventilation

Clinical Trial Details

NCT number	NCT04319939
Study type	Observational
Source	University of Chicago
Contact
Status	Active, not recruiting
Phase
Start date	February 5, 2020
Completion date	December 1, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05921656` - Construction and Evaluation of Airway Leakage Risk Model of Patients With Endotracheal Tube
Recruiting	`NCT03941002` - Continuous Evaluation of Diaphragm Function	N/A
Withdrawn	`NCT04288076` - The Brain and Lung Interaction (BALI) Study	N/A
Completed	`NCT03031860` - Semi-quantitative Cough Strength Score (SCSS)	N/A
Completed	`NCT02312869` - Local Assessment of Management of Burn Patients	N/A
Completed	`NCT02545621` - A Role for RAGE/TXNIP/Inflammasome Axis in Alveolar Macrophage Activation During ARDS (RIAMA): a Proof-of-concept Clinical Study
Completed	`NCT01885442` - TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients	N/A
Completed	`NCT01204281` - Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients	Phase 4
Terminated	`NCT01059929` - Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)	Phase 4
Completed	`NCT00824239` - Intermittent Sedation Versus Daily Interruption of Sedation in Mechanically Ventilated Patients	Phase 3
Completed	`NCT00529347` - Mechanical Ventilation Controlled by the Electrical Activity of the Patient's Diaphragm - Effects of Changes in Ventilator Parameters on Breathing Pattern	Phase 1
Unknown status	`NCT00260676` - Protective Ventilatory Strategy in Potential Organ Donors	Phase 3
Terminated	`NCT00205517` - Sedation and Psychopharmacology in Critical Care	N/A
Completed	`NCT03281785` - Ultrasound of Diaphragmatic Musculature in Mechanically Ventilated Patients.	N/A
Recruiting	`NCT04110613` - RCT: Early Feeding After PEG Placement	N/A
Completed	`NCT04410783` - The Emergency Department Sedation Pilot Trial	N/A
Recruiting	`NCT04821453` - NAVA vs. CMV Crossover in Severe BPD	N/A
Completed	`NCT03930147` - Ventilation With ASV Mode in Children	N/A
Recruiting	`NCT05029167` - REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)	N/A
Recruiting	`NCT04849039` - Lung Microbiota and VAP Development (PULMIVAP)