Does Preconditioning Affects Other Organs in Patients Undergoing Open Heart Surgery ?

Mechanical Ventilation Clinical Trial

Official title:

Variable Types of Preconditioning,is There a Different Impact Upon Multiorgan Function After Open Heart Surgery ?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03097692
• Other study ID #: IRB00009909
• Status: Completed
• Phase: N/A
• First received: March 21, 2017
• Last updated: December 20, 2017
• Start date: May 2016
• Est. completion date: March 2017

Study information

• Verified date: December 2017
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation

Description:

Preliminary evidence has suggested the role of inflammation in development and prognosis of cardiovascular diseases and cancers. Most of the prognostic studies failed to account for the effects of co-morbid conditions as these might have raised the systemic inflammation. We used neutrophil lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with cardiac preconditioning in open heart surgery .

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: March 2017
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• 18-60 years old

• American Society of Anesthesiologists physical status II and III

• Patients scheduled for open heart surgery

• no active inflammatory process

Exclusion Criteria:Exclusion Criteria:

• Emergency surgery

• Clinically significant kidney or liver disease

• Patients allergic to local anesthetic

• Patients with prolonged cardiopulmonary bypass time (>120 min)

• Patients required intra-aortic balloon pump

• Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration

Related Conditions & MeSH terms

• Mechanical Ventilation
• Neutrophil Lymphocyte Ratio
• Serum Createnine

Intervention

Procedure:
• ischemic preconditioning
ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Drug:
• Pharmacologic preconditionig
Pharmacologic preconditionig will be attained by sevoflurane anesthesia

Locations

Country	Name	City	State
Egypt	Emad Zarief Kamel Said	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change of Neutrophil lymphocyte ratio		during first two postoperative days