Mechanical Ventilation Clinical Trial
Verified date | March 2017 |
Source | Università degli Studi di Ferrara |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
. The aim of this study, thus, is to evaluate shunt fraction and markers of alveolar distress during one lung ventilation (OLV) at different levels of positive end expiratory pressure (PEEP). Moreover, investigators will focus on predicting factors of high shunt levels during OLV.
Status | Completed |
Enrollment | 41 |
Est. completion date | December 2016 |
Est. primary completion date | November 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - patients scheduled for thoracoscopic lobectomy or thoracoscopic wedge resection in lateral decubitus. - patients American Society of Anesthesiologists Physical Status Classi?cation score of 1-3 Exclusion Criteria: - Patients with hemodynamic instability, - Patients with severe chronic respiratory failure - Patients with preoperative anemia (hemoglobin <10 g 100 ml-1) - Patients requiring unplanned conversion to thoracotomy |
Country | Name | City | State |
---|---|---|---|
Italy | Azienda Ospedaliero Universitaria Sant'Anna | Ferrara |
Lead Sponsor | Collaborator |
---|---|
Università degli Studi di Ferrara |
Italy,
Beck DH, Doepfmer UR, Sinemus C, Bloch A, Schenk MR, Kox WJ. Effects of sevoflurane and propofol on pulmonary shunt fraction during one-lung ventilation for thoracic surgery. Br J Anaesth. 2001 Jan;86(1):38-43. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pulmonary shunt evaluated with ALPE system | every 30 minutes after the start of surgery up to 3 evaluations, up to 90 minutes | ||
Secondary | predictors of high intraoperative shunt | All patients admitted to the study received a preoperative physiologic assessment with a cardiovascular evaluation and spirometry. After 15 minutes of one lung ventilation, the pulmonary shunt is evaluated. Therefore, all clinical variable evaluated during preoperative assessment will be compared with the pulmonary shunt | The outcome is assessed 15 minutes after one lung ventilation |
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