Mechanical Ventilation Clinical Trial
Official title:
Assessment of Esophageal Pressure Reliability to Estimate Pleural Pressure in Critically Ill Children
Background During ventilatory assistance, optimization of settings is critical to allow a
personalized support and avoid over- or under-assistance. But little data are available in
clinical practice to guide the adjustment of the support. In adults, esophageal pressure
(PES) has been shown to be a reliable surrogate of pleural pressure (PPL) and clinical
studies suggest that PES may be useful to guide the management of mechanical ventilation. In
children, the PES measurement could have similar potential benefits, but beforehand the
reliability of PES to estimate PPL needs to be assessed.
Objective The primary objective of this study is to validate the reliability of PES directly
monitored using a miniature catheter tip pressure transducer (Gaeltec® system) to estimate
PPL, when compared to a gold standard, i.e the direct PPL measurement in situ.
Method This is a prospective single center study. Children <18 years old, hospitalized in the
pediatric intensive care unit, requiring invasive ventilation and with at least one chest
tube will be included.
Protocol A pressure transducer will be connected to the existing chest-tube and PES (measured
by Gaeltec® and feeding tube), PPL, PAW, respiratory volume and flow will be simultaneously
recorded.
Expected results We expect that the PES-based methods will provide an accurate estimation of
PPL. Once this tool validated, PES could be helpful to optimize mechanical ventilation in
children, and further interventional trials would be warranted to evaluate if its use could
allow a reduction of the ventilation support duration.
n/a
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