ED Lung Protective Ventilation to Reduce Complications

Mechanical Ventilation Clinical Trial

Official title:

The Effect of Lung Protective Ventilation Initiated in the Emergency Department on the Incidence of Pulmonary Complications and Clinical Outcomes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02543554
• Other study ID #: 201409024
• Status: Completed
• Start date: October 2014
• Est. completion date: March 2016

Study information

• Verified date: May 2018
• Source: Washington University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS). Mechanical ventilation in the emergency department (ED) has been studied infrequently when compared to the intensive care unit; however, data suggests that ED-based mechanical ventilation has significant room for improvement and may also be a causative factor in ARDS incidence.

Description:

This is a before-after study examining the impact of implementing lung protective ventilation in the emergency department.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1705
• Est. completion date: March 2016
• Est. primary completion date: March 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• mechanically ventilated via an endotracheal tube in the ED

Exclusion Criteria:

• death in the ED,

• death or discontinuation of ventilation within 24 hours,

• chronic mechanical ventilation,

• ARDS while in the ED

• transfer to another hospital.

Related Conditions & MeSH terms

• ARDS
• Mechanical Ventilation
• Ventilator-associated Conditions

Intervention

Procedure:
• lung protective ventilation
Lung protective ventilation strategy, which aims to deliver safe tidal volumes, appropriate PEEP, limit plateau pressure, and limit hyperoxia.

Locations

Country	Name	City	State
United States	Washinton University School of Medicine in St. Louis	Saint Louis	Missouri

Sponsors (1)

Lead Sponsor	Collaborator
Washington University School of Medicine

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department		7 days
Secondary	Number of Patients That Die During the Hospitalization		Patients will be followed for the duration of hospital stay