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NCT00133939 Clinical Trial

Proportional Ventilation and Ventilatory Synchronism

Mechanical Ventilation Clinical Trial

Official title:
Proportional Ventilation and Ventilatory Synchronism

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00133939
Other study ID # 2004.359
Secondary ID
Status Recruiting
Phase N/A
First received August 23, 2005
Last updated April 26, 2007

Study information
Verified date April 2007
Source Hospices Civils de Lyon
Contact Jean-Paul VIALE, MD, PhD
Phone 33 472 072
Email jean-paul.viale@chu-lyon.fr
Is FDA regulated No
Health authority France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Study type Interventional

Clinical Trial Summary

Synchronism of gas flow delivered by the ventilator and muscular effort of the patient will be studied during two kinds of ventilation. The first one is the proportional assisted ventilation during which the gas flow is theoretically adapted to the patient's muscular effort within the breath. The second is the pressure support ventilation during which the gas flow is delivered to maintain the inspiratory pressure stable. The hypothesis is that the first mode allows a better synchronism.

Recruitment information / eligibility
Status Recruiting
Enrollment 10
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Patients undergoing partial ventilatory support

Exclusion Criteria:

- Patients failing the weaning process

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Procedure:
• Mechanical ventilation

Locations
Country Name City State
France Hôpital de la Croix-Rousse Lyon

Sponsors (1)
Lead Sponsor Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

References & Publications (2)

Ganne O, Abisseror M, Menault P, Malhière S, Chambost V, Charpiat B, Ganne C, Viale JP. Low-dose ketamine failed to spare morphine after a remifentanil-based anaesthesia for ear, nose and throat surgery. Eur J Anaesthesiol. 2005 Jun;22(6):426-30. — View Citation

Méchet I, Lhuillier F, Blanchet MC, Pouyet M, Viale JP, Goudable J, Annat G, Scoazec JY, Boillot O, Liotard D, Merle E, Delafosse B. Liver function during extracorporeal whole liver perfusion in a pig model of acute ischemic liver failure. ASAIO J. 2004 Sep-Oct;50(5):503-11. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Time lag between the onset of diaphragmatic electromyogram (EMG) signal and the zero crossing of the inspiratory flow, over five minutes
Secondary Number per minute of failing breaths: breath with muscular effort without any inspiratory flow
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