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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06440148
Other study ID # SCLERMAST01
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date September 1, 2019
Est. completion date December 31, 2026

Study information

Verified date May 2024
Source Medical University of Lublin
Contact Aneta Szudy-Szczyrek, MD., PhD.
Phone +48815345468
Email aneta.szudy-szczyrek@umlub.pl
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Mastocytosis is very rare and highly heterogeneous group of disorders, characterized by the accumulation of clonal mast cells which can infiltrate several organs and tissues. Bones are the most frequent localization of systemic mastocytosis. The aim of our research was to explain the potential role of sclerostin in the pathogenesis of bone disease in mastocytosis.


Description:

Mastocytosis is a heterogeneous group of disorders, characterized by the accumulation of clonal mast cells which can infiltrate several organs, such as the skin, bone marrow or liver. The skeleton is the most frequent localization of systemic mastocytosis (SM). Bone involvement occurs in approximately 70% of SM patients. Pathogenesis of mastocytosis bone disease is poorly understood. The aim of our research is to explain the potential role of sclerostin, a recently discovered bone tissue protein, in the pathogenesis of bone changes in patients with mastocytosis. The study group consists of adult patients with mastocytosis divided according to their clinical variants of disease (aggressive systemic mastocytosis - ASM, systemic mastocytosis with an associated hematological neoplasms SM-AHN, smouldering systemic mastocytosis - SSM, indolent systemic mastocytosis - ISM and cutaneous mastocytosis - CM; and group of healthy volunteers. The concentration of sclerostin, bioactive sclerostin and expression of the SOST gene in human plasma and HMC-1.2 human mast cell culture supernatants is assessed. The Real-Time PCR method is used to evaluate the expression of sclerostin at the mRNA level, while the concentration of the sclerostin protein and its bioactive form is assessed using the enzyme immunoassay ELISA method. The obtained results are correlated with selected demographic, clinical, laboratory and radiological findings. Low-dose CT scan is used to assess bone changes. These preliminary results could serve that sclerostin may be a new therapeutic target in patients with mastocytosis.


Recruitment information / eligibility

Status Recruiting
Enrollment 50
Est. completion date December 31, 2026
Est. primary completion date May 1, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age > 18 years - Mastocytosis defined according to WHO criteria - Known KIT mutation status Exclusion Criteria: - History of organ transplant - Inability to give informed consent - Pregnancy, Breastfeeding - Vulnerable Patient, defined as: patient with another uncontrolled severe disease; patient under juridical protection

Study Design


Related Conditions & MeSH terms


Intervention

Biological:
SCLEROSTIN
Pathogenesis of mastocytosis bone disease

Locations

Country Name City State
Poland Department of Hematooncology and Bone Marrow Transplantation Lublin Lubelskie

Sponsors (1)

Lead Sponsor Collaborator
Medical University of Lublin

Country where clinical trial is conducted

Poland, 

Outcome

Type Measure Description Time frame Safety issue
Primary plasma sclerostin measurements (in pmol/l) SOST gene expression by Real-Time PCR dimensions of osteolytic lesions on low-dose computed tomography (in mm) dimensions of osteosclerotic lesions on low-dose computed tomography (in mm) The Primary Outcome Measures concern:
the measurements of plasma levels of sclerostin and its bioactive form in patients with mastocytosis and healthy volunteers
the measurements of levels of sclerostin and its bioactive form in HMC-1.2 human mast cells unstimulated and stimutaled with Il-6
1 year
Primary dimensions of osteolytic lesions (in mm) The Primary Outcome Measures concern:
- the measurements of the dimensions of osteolytic bone lesions on low-dose computed tomography in patients with mastocytosis
1 year
Primary dimensions of osteosclerotic lesions (in mm) The Primary Outcome Measures concern:
- the measurements of the dimensions of osteosclerotic bone lesions on low-dose computed tomography in patients with mastocytosis
1 year
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