Marfan Syndrome Clinical Trial
— MARF'HOMEOfficial title:
Evaluation of the Effects of Personalized Training at Home Combining Endurance and Resistance in Patients Suffering From Marfan Syndrome
Verified date | September 2022 |
Source | French Cardiology Society |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Marfan syndrome (MS) is an autosomal dominant genetic disorder caused by a mutation in the fibrillin-1 gene (FBN1) encoding the protein fibrillin-1. Fibrillin is the main component of microfibrils, elements found in all of the body's tissues, and this pathology is characterized by the multitude of its clinical manifestations. These patients may develop aneurysms in the aortic root and one of the main factors of morbidity in patients with MS is aortic dissection. Prevention mainly involves preventive aortic surgery. However, the repercussions are global and can affect the functioning of other tissues such as skeletal muscle tissue, bone tissue, lung tissue and the eyes. The association of skeletal (scoliosis, hyperlaxity), muscular and ocular disorders is clearly associated with an impairment in the quality of life. These disorders are associated with pain and disability which affect professional activity, leisure and family life. Physical activity could represent a relevant alternative for these patients. A recent animal study suggests that moderate training is beneficial.
Status | Completed |
Enrollment | 72 |
Est. completion date | September 30, 2022 |
Est. primary completion date | September 30, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - patient with Marfan syndrome and followed up at Bichat Claude Bernard hospital, Paris. Marfan syndrome should be diagnosed according to the Ghent nosology revised in 2010 - Patient taking protective treatment for the aorta (beta blocker, calcium channel blocker, ACE inhibitor, angiotensin II receptor antagonist). - Valid patient, able to return to consultation and carry out functional assessments and personalized physical training at home. - Patients operated prophylactically on the ascending aorta may be included at a distance > 6 months from their surgery. Exclusion Criteria: - Myocardial pathology other than Marfan syndrome. - Thoracic aorta dissection. - Aortic diameter > 45 millimeters. - Uncontrolled high blood pressure at rest (systolic blood pressure > 140 Millimeter of mercury and diastolic blood pressure > 90 Millimeter of mercury) - Increase in systolic blood pressure > 160 Millimeter of mercury during exercise. - Pregnancy at the time of the study |
Country | Name | City | State |
---|---|---|---|
France | Groupe Hospitalier Bichat - Claude Bernard | Paris |
Lead Sponsor | Collaborator |
---|---|
French Cardiology Society |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Quality of life assessment: questionnaire | Assessed with Medical Outcome Study Short Form 36 questionnaire, a scale scored on a 0 to 100 range so that the lowest is the worth condition and highest is the best condition. | 3 months | |
Secondary | Pain assessment: Fibromyalgia Rapid Screening Tool | Assessed with Fibromyalgia Rapid Screening Tool | 3 months | |
Secondary | Self-perception assessment | Assessed with Physical Self Inventory questionnaire, a scale scoring 25 items rated on a 6-point scale ranging from 1 (Not at all) to 6 (Entirely) and assessing 6 dimensions (global self-worth (10-50), physical self-worth (10-50), physical condition (10-50), sport competence (10-40), physical attractiveness (10-30), and physical strength (10-30)) of the physical self-conception. | 3 months | |
Secondary | Aortic diameter | Evolution of the aortic diameter (in millimeter) in echocardiography, safety cardiovascular parameters | 3 months | |
Secondary | Blood pressure | Evolution of the systolic and diastolic blood pressures (in Millimeter of mercury) during exercise, monitoring of physiological parameters | 3 months | |
Secondary | Heart rate | Evolution of heart rate (Beats per minute) during exercise, monitoring of physiological parameters | 3 months | |
Secondary | oxygen consumption | Evolution of oxygen consumption (in liter) during exercise, monitoring of physiological parameters | 3 months | |
Secondary | Maximal voluntary contraction | Evolution of maximal voluntary contraction (in Newtons) during exercise, monitoring of physiological parameters | 3 months | |
Secondary | Left Ventricular Ejection Fraction (LVEF) | Evolution of Left Ventricular Ejection Fraction (in percentage) at rest, monitoring of cardiovascular parameters. | 3 months | |
Secondary | Global longitudinal strain (GLS) | Evolution of GLS (in percentage) at rest, monitoring of cardiovascular parameters | 3 months |
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