Development of a Blood Test for Marfan Syndrome

Status Recruiting

Clinical Trial Summary

The objective of this study is to determine whether a simple blood test can be a useful clinical tool for monitoring aortic disease in Marfan syndrome and Marfan-related disorders.

Clinical Trial Description

The primary objective of this study is to determine whether increased quantitites of circulating microfibril fragments, measured with a simple blood test, are associated with aortic root size and increased growth of the aortic root in Marfan syndrome and related disorders. The secondary objectives of this study are to: (1) Determine a Marfan "signature" profile of circulating microfibril fragments. (2) Determine if high concentrations of fibrillin-1 fragments are associated with large aortic root diameters. (3) Determine which fibrillin-1 fragments are good biomarkers for aortic root growth and size in Marfan syndrome. (4) Determine the relation between fibrillin-1, aortic root diameter, and medical and lifestyle factors reported on questionnaires. ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02148900
Study type	Observational [Patient Registry]
Source	Shriners Hospitals for Children
Contact	Lynn Y. Sakai, Ph.D.
Phone	503-221-3436
Email	lys@shcc.org
Status	Recruiting
Phase	N/A
Start date	May 2013
Completion date	December 2017

View Details

See also
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