Clinical Trials Logo

Clinical Trial Summary

To use 18F-DCFPyL imaging agent and PET/CT to detect none prostate cancer solid malignancies and schwannoma tumors.


Clinical Trial Description

The purpose of this protocol is to extend our existing patient base from those with prostate cancer to those with any solid malignancy - as well as patients with schwannoma, a non-malignant solid tumor that also over-expresses GCP II. Using our first generation imaging agent, [18F]DCFBC, we have shown that we could detect GCP II in tissue specimens of patients with a variety of cancers, and vestibular schwannoma. We have also shown that GCP II may not only be present in the neovasculature of solid (non-prostate) tumors, but also reside within the tumor epithelium itself. We have shown that to be the case for melanoma, in particular. Our goal is to leverage the broad utility of our GCP II targeted imaging agents for managing other cancers. In addition to schwannoma, the cancers we intend to target include but will not be restricted to: head and neck cancer, salivary gland tumors, renal cell carcinoma, transitional cell carcinoma, colorectal cancer, gastric cancer, neuroendocrine cancer, glioblastoma, melanoma, pancreatic cancer, non-small cell lung cancer, soft tissue sarcoma, breast cancer, endometrial cancer, ovarian cancer, lymphoma and multiple myeloma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03542773
Study type Interventional
Source Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Contact
Status Completed
Phase Phase 1
Start date February 6, 2015
Completion date May 1, 2022

See also
  Status Clinical Trial Phase
Completed NCT02041871 - Interest of PReOPerative Immunonutrition in Liver Surgery for Cancer N/A
Completed NCT03110783 - Bioseal Dural Sealing Study BIOS-14-001 Phase 3
Recruiting NCT05516914 - A Phase Ib/II Clinical Trial of LBL-007 Combined With Tislelizumab in the Treatment of Malignant Tumors Phase 1/Phase 2
Completed NCT02534506 - Study of Urelumab in Subjects With Advanced and/or Metastatic Malignant Tumors Phase 1
Recruiting NCT05714748 - Application of mRNA Immunotherapy Technology in Epstein-Barr Virus-related Refractory Malignant Tumors Phase 1
Recruiting NCT05987098 - BBPA PET/CT in Patients With Malignant Tumors N/A
Not yet recruiting NCT01092247 - The Effect of Ketogenic Diet on Malignant Tumors- Recurrence and Progress N/A
Recruiting NCT03160599 - Restricted Calorie Ketogenic Diet as a Treatment in Malignant Tumors N/A
Recruiting NCT04702841 - CAR - γ δ T Cells in the Treatment of Relapsed and Refractory CD7 Positive T Cell-derived Malignant Tumors Early Phase 1
Completed NCT00165100 - Dynamic Area Telethermometry (DAT) as an Imaging Modality in Patients With Cancer N/A
Suspended NCT05615974 - A Phase I/II Study of LM-101 Injection in Patients With Advanced Malignant Tumors Phase 1/Phase 2
Completed NCT05293990 - Usefulness of Gadovist-enhanced FLAIR Imaging N/A
Completed NCT01509612 - Additive Homeopathy in Cancer Patients Phase 3
Completed NCT01678690 - An Exploratory Study of Gemcitabine Hydrochloride Oral Formulation (D07001-F4) in Subjects With Malignant Tumors Phase 0
Suspended NCT06270394 - FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application N/A
Completed NCT00412503 - Temozolomide in Association With Topotecan in Refractory or Relapsed Malignant Tumors in Children and Adolescents Phase 1