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Neurilemmoma clinical trials

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NCT ID: NCT06313411 Recruiting - Clinical trials for Endometriosis Pelvic

How do I Perform a Laparoscopic Removal of a Pelvic Retroperitoneal Schwannoma

PRS
Start date: November 23, 2022
Phase:
Study type: Observational

Schwannomas are mainly benign tumors, which develop mainly in the skull or in the cervical region. Retroperitoneal location is rare, since it represents between 0.5 and 5% of scwhanomas. The malignant retroperitoneal form is, however, more common than in other locations. Retroperitoneal schwannoma is often discovered during the exploration of unexplained lumbo-pelvic pain, or in the face of compression of nearby organs. Abdominopelvic CT and magnetic resonance imaging are essential to characterize the mass and verify its extension. The precise diagnosis is based on the pathological examination of the part, and complete surgical excision is the standard treatment. Acquiring the surgical techniques and skills necessary to carry out these types of procedures is essential to providing optimal patient care.

NCT ID: NCT06163664 Not yet recruiting - Clinical trials for Vestibular Schwannoma

Role of ChatGPT in Vestibular Schwannoma Management

Start date: December 15, 2023
Phase: N/A
Study type: Interventional

Previous studies have demonstrated that patients frequently undergo significant decision conflict regarding major medical decisions in otolaryngology. There lack validated tools available for decision support for patients. While limited evidence has demonstrated that clinical decision support tools can alleviate decision conflict for patients with diagnosis in otolaryngology, conversational language models were not employed in these studies and may provide additional benefit in this context. This study seeks to evaluate the efficacy of using ChatGPT, a conversational language model with basic clinical knowledge, in alleviating decision conflict for patients with new diagnosis in otolaryngology. For this pilot study, vestibular schwannoma, a benign tumor that develops on the vestibular nerve with known clinical equipoise, has been chosen for the initial study diagnosis. Efficacy will be evaluated by comparison of responses to the Decisional Conflict Scale (DCS) and Satisfaction with Decision (SWD) scores between a group given training in ChatGPT and a control group (no ChatGPT training).

NCT ID: NCT06112509 Not yet recruiting - Clinical trials for Vestibular Schwannoma

Evolution of Vestibular Function After Treatment of a Vestibular Schwannoma by Gamma-knife Radio-surgery

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the vestibular effects of gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

NCT ID: NCT05786144 Recruiting - Clinical trials for Vestibular Schwannoma

Vestibular Schwannoma Organoids

Start date: June 1, 2020
Phase:
Study type: Observational

In standard of care regularly planned surgery, tissue will be obtained from patients who are suspicious for having vestibular Schwannoma (on MRI). The tissue that remains after the pathologist gathered sufficient for analysis, the remaining tissue is used for creating tumour stem cell organoids.

NCT ID: NCT05702749 Recruiting - Clinical trials for Vestibular Schwannoma

Evaluating Pre-Treatment Vestibular Physical Therapy Rehab for Patients With Vestibular Schwannomas

VS PREHAB
Start date: January 22, 2024
Phase: N/A
Study type: Interventional

The study is a pilot efficacy study. The investigators aim to estimate mean baseline and post-treatment balance scores among Vestibular Schwannomas (VS) patients undergoing pretreatment rehab (PREHAB) or no PREHAB when managed with either surgery or radiosurgery.

NCT ID: NCT05684835 Recruiting - Schwannoma of Neck Clinical Trials

Radiographic Prediction of the Nerve Origin of Neck Peripheral Nerve Sheath Tumors

Start date: January 1, 2008
Phase:
Study type: Observational

Postoperative nerve palsy is a major complication following resection of neck peripheral nerve sheath tumors. This study is a retrospective cohort aimed to predict the nerve origin of neck peripheral nerve sheath tumors. Accurate preoperative identification of the nerve origin can improve surgical outcomes and patient counseling

NCT ID: NCT05684692 Recruiting - Pain, Chronic Clinical Trials

Screening Trial for Pain Relief in Schwannomatosis (STARFISH)

Start date: August 31, 2023
Phase: Phase 2
Study type: Interventional

This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple experimental therapies simultaneously in participants with moderate-to-severe pain due to schwannomatosis (SWN). This Master Study is being conducted as a platform that may allow participants with pain associated with schwannomatosis to receive a novel intervention throughout this study. Embedded within the Master Study are individual drug sub-studies: - Investigational Drug Sub-Study A: Siltuximab - Investigation Drug Sub-Study B: Erenumab-Aooe

NCT ID: NCT05641441 Recruiting - Clinical trials for Vestibular Schwannoma

Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma

Start date: January 24, 2023
Phase:
Study type: Observational

The investigators aim to study the impact of stereotactic radiosurgery, for the treatment of vestibular Schwannoma, on the cochlear, vestibular, gustatory, and facial nerve functions and compare it with a conservatively treated group. The predictive value of radiological tumor characteristics on hearing preservation and vestibular function will be also evaluated. Additionally, the investigators will invite patients with vestibular Schwannoma to fill out questionnaires to assess their quality of life.

NCT ID: NCT05622344 Recruiting - Vestibular Disorder Clinical Trials

StableEyes With Active Neurofeedback

SWAN
Start date: August 8, 2022
Phase: N/A
Study type: Interventional

The investigators have developed a self-administered rehabilitation tool that incrementally guides the user to increase head motion to mitigate motion sickness and enhance postural recovery following centrifugation or unilateral vestibular nerve deafferentation surgery.

NCT ID: NCT05578560 Recruiting - Clinical trials for Acute Peripheral Vestibulopathy Following Surgical Procedure

The Use of Virtual Reality in Rehabilitation in Patients After Vestibular Schwannoma Surgery.

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

Resection of the vestibular schwannoma leads to acute peripheral or combined vestibular loss caused by a surgical lesion to the branches of the vestibular nerve and, less frequently also the lesion of the cerebellum. The lesion presents in patients with postural instability, vertigo, oscillopsia, and vegetative symptoms that may accompany it. The organism reacts to this state with the process of central compensation with the significant role of the cerebellum. The goal of the rehabilitation is to support this process and thus to make recovery faster and more efficient since not all patients are capable of complete restoration of the vestibular function. Up to date, rehabilitation includes, apart from the specific vestibular exercise, also the possibility of modern techniques using virtual reality space and prehabituation. Thanks to prehabituation, i.e., chemical labyrinthectomy with intratympanically installed gentamicin, the timing of the origin of the acute vestibular loss and the surgical procedure is separated. Therefore, there is a chance of achieving vestibular compensation before vestibular schwannoma removal. In the last decade, due to the advances in technology in the field of computer games and the applications for smartphones, the tools for virtual reality have become less expensive and more available in common praxis. Virtual reality is a technique for generating an environment that can strengthen three-dimensional optokinetic stimulation, subsequently the process of central compensation. Overall, it may shorten the time of recovery after the surgery and improve patients' quality of life.