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A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion

Lung Cancer Clinical Trial

Official title:
A Phase Ib/II Study of IV Nivolumab and Intrapleural Talimogene Laherparepvec for Patients With Malignant Pleural Effusion

Clinical Trial Summary

This is a Phase Ib/II clinical trial to evaluate the feasibility of administering talimogene laherparepvec into the intrapleural space of subjects with malignant pleural effusion through a pleurX catheter.

Clinical Trial Description

This is a phase 1b/II clinical trial that includes a safety run-in cohort to investigate the novel approach of administering intrapleural talimogene laherparepvec via a pleurX catheter in patients with known malignant pleural effusion (MPE). In Phase Ib of this study, the safety of infusing talimogene laherparepvec directly into the pleural cavity of subjects diagnosed with MPE, through pleurX catheter, will be tested. In Phase II of this study, after establishing the safety of the above mentioned approach, 24 subjects will enrolled and treated with intrapleural talimogene laherparepvec and IV nivolumab. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03597009
Study type Interventional
Source UNC Lineberger Comprehensive Cancer Center
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date March 6, 2019
Completion date February 12, 2020
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