Malignant Neoplasm Clinical Trial
Official title:
A Pilot Study of Bovine Lactoferrin in Cancer Patients Reporting Taste Disturbances While Receiving Chemotherapy
This pilot phase II trial studies how well bovine lactoferrin supplement works in improving taste in patients with cancer receiving chemotherapy. Bovine lactoferrin supplement may help improve the ability to taste food in patients who are receiving chemotherapy.
PRIMARY OBJECTIVES:
I. To assess the impact of lactoferrin supplementation (bovine lactoferrin supplement) on
self-reported taste and smell disturbances in cancer patients receiving chemotherapy.
SECONDARY OBJECTIVES:
I. To assess the impact of lactoferrin supplementation on the baseline lipid peroxidation
byproducts in saliva in cancer patients as measured by the thiobarbituric acid reactive
substances (TBARs) assay.
II. To assess the impact of lactoferrin supplementation on the ability of cancer patients to
generate increased lipid peroxidation byproducts when challenged with a weak iron-containing
solution.
III. To assess the impact of lactoferrin supplementation on self-reported general quality of
life and on specific self-reported anorexia/cachexia issues in cancer patients with
established chemotherapy-induced taste disturbances.
IV. To assess the incidence of vitamin D deficiency in cancer patients with chemotherapy
induced taste changes.
OUTLINE:
Patients receive bovine lactoferrin supplement orally (PO) three times daily (TID) for 1
month.
After completion of study treatment, patients are followed up at 2 weeks and 1 month.
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