Brain Imaging Changes Following Proton Therapy for Pediatric Primary Central Nervous System and Base of Skull Tumors

Malignant Central Nervous System Neoplasm Clinical Trial

Official title:
Assessment of Predicted LET and Dosimetry in Relation to White Matter Changes in Pediatric Patients Following Proton Therapy for Primary Central Nervous System and Base of Skull Malignancies: A Pilot Study

Status Active, not recruiting

Clinical Trial Summary

This trial gathers information from patients with primary central nervous system or base of skull tumors that receive proton beam therapy and see if certain imaging techniques can help detect radiation-related changes over time. This study may help providers learn more about proton beam radiotherapy and how to improve the way it is delivered.

Clinical Trial Description

PRIMARY OBJECTIVE: I. To establish linear energy transfer (LET)-based models as early predictors for white matter changes on magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) sequences in pediatric patients following proton beam therapy for primary central nervous system (CNS) and base of skull tumors. OUTLINE: Patients' medical charts are reviewed. ;

Study Design

Related Conditions & MeSH terms

Central Nervous System Neoplasms
Malignant Central Nervous System Neoplasm
Malignant Skull Base Neoplasm
Neoplasms
Nervous System Neoplasms
Skull Base Neoplasms

Clinical Trial Details

NCT number	NCT04296617
Study type	Observational
Source	Mayo Clinic
Contact
Status	Active, not recruiting
Phase
Start date	January 21, 2019
Completion date	June 21, 2026

View Details

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