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Pyronaridine-artesunate With Low Dose Primaquine for Preventing P. Falciparum Transmission — NECTAR1  

Malaria,Falciparum Clinical Trial

Official title:
The Efficacy and Safety of Pyronaridine-artesunate Combined With Low Dose Primaquine for Preventing Transmission of P. Falciparum Gametocytes in Sub-Saharan Africa

Clinical Trial Summary

The purpose of this study is to assess the gametocytocidal and transmission reducing activity of pyronaridine-artesunate (PA) and dihydroartemisinin-piperaquine (DP) with and without a single low dose of primaquine (PQ; 0.25mg/kg). Outcome measures will include infectivity at 2 and 7 days after treatment, the duration of infectivity in the artemisinin combination therapy (ACT) only arms, and the production and detectability of histidine rich protein II.

Clinical Trial Description

Protocol will be shared on request ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04049916
Study type Interventional
Source London School of Hygiene and Tropical Medicine
Contact
Status Completed
Phase Phase 2/Phase 3
Start date September 12, 2019
Completion date January 7, 2020
View Details
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