Malaria,Falciparum Clinical Trial
Official title:
A Phase Ia Study to Assess Safety and Immunogenicity of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs25-IMX313 in Matrix-M1 Adjuvant in Healthy Adults Living in the UK
This is an open label, single-site, first-in-human, Phase Ia study to assess safety and
immunogenicity of the Plasmodium falciparum malaria vaccine candidate Pfs25-IMX313 in
Matrix-M1 adjuvant in healthy adults living in the UK
Volunteers will receive 3 doses of vaccine over 2 months and will be followed up for
approximately 8 months.
This Phase 1a clinical trial is designed primarily to assess the safety and tolerability of
the Pfs25-IMX313/Matrix-M transmission blocking vaccine in healthy adult volunteers. An
important secondary objective is to to assess the immune response to the vaccine.
8 volunteers will receive 3 doses of 10µg Pfs25-IMX313 in 50 µg Matrix-M1 on days 0, 28 and
56. Blood samples will be taken for safety testing and to collect information about the
immune response. Any symptoms that occur after vaccination will also be recorded.
Healthy volunteers aged 18-45 will be recruited in England at the Centre for Clinical
Vaccinology and Tropical Medicine, Churchill Hospital, Oxford.
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