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Safety, Immunogenicity and ex Vivo Efficacy of Pfs25-IMX313/Matrix-M in Healthy Volunteers in Bagamoyo, Tanzania.

Malaria,Falciparum Clinical Trial

Official title:
A Phase Ib Age De-escalation and Dose Escalation Open Label Clinical Trial of the Safety, Immunogenicity and ex Vivo Efficacy of a Candidate Malaria Vaccine Pfs25-IMX313/Matrix-M Administered Intramuscularly in Healthy Adults and Young Children in Tanzania.

Clinical Trial Summary

A phase Ib age de-escalation and dose escalation open label clinical trial of the safety, immunogenicity and ex-vivo efficacy of a candidate malaria vaccine Pfs25-IMX313/Matrix-M administered intramuscularly in healthy adults and young children in Tanzania

Clinical Trial Description

This study aims to evaluate safety, immunogenicity, and transmission blocking activity of Pfs25IMX313-Matrix-M in healthy Tanzanian adults and children naturally exposed to malaria in Bagamoyo district, Tanzania. The study will enrol 45 volunteers comprising of 13 adults (18-45 years) and 32 children (5-12 years). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04271306
Study type Interventional
Source University of Oxford
Contact Angela Minassian
Phone +44865611425
Email angela.minassian@ndm.ox.ac.uk
Status Recruiting
Phase Phase 1
Start date May 25, 2021
Completion date March 2023
View Details
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