Major Depressive Disorder (MDD) Clinical Trial
Official title:
Optimization of Intravenous Ketamine for Treatment-Resistant Depression: A Randomized, Placebo-Controlled, Triple-masked, Clinical Trial
Existing treatments for major depressive disorder (MDD) generally take weeks to months to
exert their maximal benefit. There is an urgent need to develop rapid-acting treatments for
MDD. Ketamine, a high-affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist,
has been used as a standard intravenous (IV) anesthetic agent for many years in both
pediatric and adult patients. Beyond its well-established role in anesthesia and pain
management, there is emerging evidence that ketamine may have rapid antidepressant
properties for patients with severe mood disorders.
In this study we are investigating whether ketamine can have an antidepressant effect
compared to midazolam. Midazolam has similar anesthetic effects compared to ketamine but has
not been shown to be an antidepressant, and is therefore acting as an active control in this
study.
The study period can last up to 8 weeks, depending on your response to the study medication.
There are two required overnight stays in our Research Commons as part of this study.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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