Effect of Antidepressants on White Matter Structure

Status Recruiting

Clinical Trial Summary

Subjects with major depression will be evaluated and intensively characterized through questionnaires, computerized cognitive evaluation and laboratory investigations. Magnetic resonance imaging will be used to document baseline white matter structure. subjects will then receive desvenlafaxine which will be adjusted as clinically indicated. After 16 weeks the evaluations will be repeated.

Clinical Trial Description

40 subjects will be included in the study. Diagnosis will be confirmed by MINI. Participants will be characterised using questionnaires, pain threshold, cognition, facial expression recording and MRI. Desvenlafaxine will be initiated at 50mg AM. At week 8 Desvenlafaxine may be increased to 100mg as clinically indicated. Measures will be repeated at the end of the study. ;

Study Design

Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01492621
Study type	Interventional
Source	Centre de recherche Fernand-Seguin, Hôpital Louis-H. Lafontaine
Contact	souad Lahlafi, BNurs
Phone	5142514000
Email	slahlafi.crfs@ssss.gouv.qc.ca
Status	Recruiting
Phase	Phase 4
Start date	November 2011
Completion date	November 2013

View Details

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