Major Depression Clinical Trial
Official title:
Thyroid Axis in Major Depression
This study will evaluate the effectiveness of treatment with supplemental triiodothyronine (T3, Cytomel) and sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI), in improving symptoms of major depressive disorder (MDD).
The primary hypothesis is that triiodothyronine (Cytomel) supplementation of the
antidepressant sertraline (Zoloft) will result in a greater improvement in HAM-D scores
compared to placebo in the treatment of Major Depressive Disorder (MDD).
The goals of this proposal are to examine the relationship between Major Depressive Disorder
(MDD) and abnormalities of the hypothalamic pituitary thyroid (HPT) axis. This protocol will
systematically examine the value of supplemental triiodothyronine (T3, Cytomel) with
sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI) in the treatment of
MDD. The focus will be on two overlapping populations: 1) those with evidence of HPT
abnormalities, and 2) those who did not respond to a previous adequate SSRI trial
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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