Major Depression Clinical Trial
Official title:
Treatment of Therapy-Resistant Major Depression With Transcranial Stimulation rTMS in Combination With Escitalopram
A doubleblind randomised trial with active versus sham rTMS in combination with escitalopram in patients with prior treatment resistant depression in an acute 12 weeks trial with subsequent 24 weeks study phase with active versus placebo citalopram
In this study we aimed at investigating to what degree rTMS applied over the left
dorsolateral cortex relieves depressive symptoms when the treament is combined with
antidepressive medication. The study will also be able to supply knowledge on how long any
possible effect of the rTMS treatment lasts.
In the first 12 weeks of the trial participants are randomised to either rTMS combined with
escitalopram or sham rTMS combined with escitalopram. rTMS is given daily for the first 3
weeks.
The next phase is a relapse prevention study where the responders from the initial phase are
randomised to either active or placebo escitalopram for 24 weeks.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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