Magnesium Therapy on Cerebral Palsy Patients Clinical Trial
Official title:
Effect of Oral Magnesium Therapy on Constipation on Children With Cerebral Palsy
The aim of this study is to study the therapeutic and adverse effects of oral magnesium sulfate therapy on constipation in children with spastic cerebral palsy suffering from chronic constipation in neuro pediatric unit at Assiut University Hospital.
Children with cerebral palsy (CP) often experience many comorbidities such as
constipation,which is considered a frequent problem in spastic (cp)children .It occurs due to
reduced mobility, difficulties in feeding and as a side effect of many muscle relaxing
medications.It is estimated that 74% of children with cerebral palsy suffer from constipation
,which necessitates use of laxatives. Magnesium sulfate has a famous role as being an osmotic
laxative,which is the first step in the pharmacological treatment of constipation
• Mechanism of action of mg sulphate: They are poorly absorbed by the intestinal wall, which
leads to intraluminal accumulation of hyperosmolar particles. This stimulates retention of
water in the intestinal lumen, softening the stools and increasing peristalsis through
intestinal distension. It acts by accelerating small intestinal transit both in fasting and
in fed state and it tends to increase the frequency and weight of stools, compared with
placebo.In addition ,It increases intraluminal secretion of cholecystokinin and increases
nitric oxide (NO) release.
• Side effects of mg sulphate: Reducing the intestinal absorption of fat, protein and
carbohydrates following solid meal ingestion
• other drugs used as laxative in cp and there side effects:
- Lactulose: it can lead to distention, bloating and excess flatus. In some individuals
these side-effects may limit the use of this product.
- Glycerin: is another small molecule that can exert osmotic activity in the colon. It is
not absorbed by the colon and is used as a suppository to draw water into the rectum to
produce a bowel movement. It is well absorbed by the small intestine, and hence cannot
be taken by oral route.
- The aim of this study is to study the therapeutic and adverse effects of oral
magnesium sulfate therapy on constipation in children with spastic cerebral palsy
suffering from chronic constipation in neuro pediatric unit at Assiut University
Hospital.
;