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Clinical Trial Summary

The goal of this clinical trial is to clarify the efficacy of anti-vascular endothelial growth factor (anti-VEGF) drugs combined with subthreshold micropulse laser (SML) therapy on retinal function and anatomical recovery in patients with diabetic macular edema (DME). The main questions it aims to answer are: - To clarify the efficacy of anti-VEGF drugs combined with SML therapy on retinal function and anatomical recovery in DME patients. - To explore the changes in visual acuity and optical coherence tomography angiography (OCTA) parameters before and after the treatment of DME with anti-VEGF drugs combined with SML, and further explore the changes in morphological characteristics of retinal microvessels and the potential treatment mechanism. Participants will randomly be given Intravitreous injection of anti-VEGF drugs or anti-VEGF drugs combined with SML therapy. All participants will be followed up for 6 months after treatment.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT05759884
Study type Interventional
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact Zhiyong Zhang, MD. PhD.
Phone 13968059392
Email zhangzhiyong@zju.edu.cn
Status Recruiting
Phase N/A
Start date February 1, 2022
Completion date June 2024