NSCLC Clinical Trial
Official title:
Prognostic Impact of the Kind of Lymphadenectomy and Lymph Node Characteristics on Node-positive Patients Underwent Anatomical Lung Resection With or Without Adjuvant Therapy for Non-Small Cell Lung Cancer
Adjuvant therapy in patients affected by NSCLC is indicated in surgically treated cases of N2
disease, while the actual guidelines reported the possibility of a case-by-case decision in
case of N1 involvement.
On the other hand, the actual categorization of patients based on the hilar or mediastinal
involvement (N1 or N2) risks to be too ineffective and straightforward for prognosis
prediction and an indication of adjuvant treatments. This issue was underlined in the 8th TNM
proposal for the N sub-classification, with a final proposal of different subgroups based on
the number of involved stations. However, the IASLC committee noted that this proposal
presented some limits due overlapping or not statistical significance among some survival
curves, so the proposal was not adopted in the staging system. Moreover, the committee stated
that the lack of information regarding some data such as the number of the resected or the
metastatic nodes might affect the results and limited other proposals.
The objectives of this study are:
- To evaluate the prognostic role of the kind of lymphadenectomy, the number of the
resected and/or metastatic lymph nodes in surgically treated N positive patients in
terms of survival.
- To evaluate the indication and the role of adjuvant treatments in these patients.
- To identify patients with increased risk of early recurrence or poor survival based on
the lymph node involvement characteristics In particular, data will be collect in a
prospective database including clinical and pathological data, kind of lymphadenectomy,
number of resected nodes, number of metastatic nodes, kind and schedule of adjuvant
therapy and follow-up status
n/a
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