Fluorescence Laparoscopic Navigation for Rectal Cancer and Sigmoid Colon Cancer — FLORA-01  

Colorectal Neoplasms Clinical Trial

Official title: A Randomized Controlled Trial of Fluorescence Laparoscopic Navigation of the Extent of Lymph Node Dissection for High Rectal Cancer and Sigmoid Colon Cancer

Status Not yet recruiting

Clinical Trial Summary

To explore the short-term and long-term outcomes of fluorescence laparoscopic navigation D2 lymph node dissection for colorectal cancer surgery by comparing it with D3 lymph node dissection.

Clinical Trial Description

Lymph node metastasis is the most common metastatic mechanisms for colorectal cancer. Therefore, regional lymph node dissection is the key part in radical surgery for colorectal cancer. In patients who have developed lymph node metastases, inadequate lymph node dissection will promote tumor recurrence. In patients who do not develop lymph node metastases, excessive lymph node dissection not only does not improve the patient's prognosis, but also increases surgical trauma and destroys the antitumor effect of the lymphoid immune system. There is still some controversy over whether to choose D3 lymph node dissection or D2 lymph node dissection for rectal and sigmoid cancer. Fluorescence laparoscopic navigation techniques can guide lymph node dissection by visualizing lymph nodes more clearly during surgery.

This study will compare the short-term and long-term oncological outcomes between fluorescence laparoscopic navigation D2 and D3 lymph node dissection by conducting a randomized controlled trial. ;

Related Conditions & MeSH terms

• Colorectal Neoplasms
• Fluorescence
• Lymph Node Excision
• Sigmoid Neoplasms

• NCT number: NCT05730595
• Study type: Interventional
• Source: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
• Contact: Jianqiang Tang, Dr.
• Phone: +8613661090036
• Email: doc_tjq@hotmail.com
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 1, 2023
• Completion date: June 1, 2027