Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases

Lung Injury Clinical Trial

Official title:

To Study the Clinical Treatment Plan of Lung Injury Caused by Major Infectious Diseases Treated With Stem Cells

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06416709
• Other study ID #: KY-2023-2-6-2
• Status: Recruiting
• Phase: Phase 1/Phase 2
• Start date: May 10, 2023
• Est. completion date: May 10, 2026

Study information

• Verified date: May 2024
• Source: Cell Energy Life Sciences Group Co. LTD
• Contact: Zhe Xu, Dr
• Phone: 86 150 0111 1836
• Email: xuzhe302[@]139.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this study is to conduct a prospective, double-blind, randomized placebo-controlled clinical trial to investigate the safety and efficacy of mesenchymal stem cells treatment for Lung injury caused by major infectious diseases.

Description:

For patients with lung injury caused by major infectious diseases, conventional antiviral and anti-inflammatory treatments may not effectively improve lung function in the short term and may increase the risk of secondary infections. Therefore, in the clinical management of viral pneumonia, it is necessary to consider the lung tissue damage caused by acute viral replication and systemic immune stress, while also focusing on the subsequent lung functional impairment due to virus clearance-induced pulmonary fibrosis. Studies have shown that after peripheral intravenous administration of mesenchymal stem cells (MSCs), approximately 50% to 60% of the cells remain in the lung tissue within 1 hour, decreasing to around 30% after 3 hours. After 48 hours, MSCs tend to aggregate in the liver and spleen, and cell retention can still be detected 10 days later. MSCs aggregation in the lung tissue can secrete cell trophic factors such as keratinocyte growth factor (KGF), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF), promoting the regeneration of type II alveolar epithelial cells, improving the pulmonary microenvironment, and facilitating the repair of the alveolar epithelial barrier after ARDS injury.This study is intended to conduct a prospective, double-blind, randomized placebo-controlled clinical trial to investigate the safety and efficacy of mesenchymal stem cells treatment for Lung injury caused by major infectious diseases.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: May 10, 2026
• Est. primary completion date: May 10, 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

1. Age =18 years old;

2. Understand and sign the informed consent form, comply with the relevant requirements of this study, and agree not to participate in other studies and not to receive other immunotherapy during the study participation;

3. meet the diagnosis of viral pneumonia and are in the advanced stage of disease: (1)The etiological diagnosis met any of the following criteria:

?Sars-cov-2 infection: Respiratory specimens (nasal/throat swabs or bronchial secretions/bronchoalveolar lavage fluid) were positive for Sars-cov-2 nucleic acid and/or antigen within 14 days;

?Adenovirus infection: positive for adenovirus nucleic acid and/or antigen in respiratory secretions or blood within 14 days;

?Influenza virus infection: positive respiratory secretions or blood for influenza virus nucleic acid and/or antigen within 14 days;

?Other respiratory virus antigens or nucleic acids were positive in respiratory secretions or blood within 14 days; (2)Imaging manifestations: chest X-ray or CT was consistent with the imaging features of viral pneumonia, manifested as multiple patchy shadows, ground glass shadows or consolidation in both lungs; (3)Respiratory System Indicators:Respiratory distress, respiratory rate (RR) =30 breaths/min at rest; In the resting state, oxygen saturation of finger pulse was =93% while breathing air; Oxygen and index (partial pressure of arterial oxygen/fraction of inspired oxygen) =300mmHg and > 200mmHg;

4. Invasive mechanical ventilation and vasopressor medications were not required.

Exclusion Criteria:

1. Patients tested active for HBV, HCV, HIV, or tuberculosis at the time of screening;

2. patients with solid tumors, leukemia or mental disorders;

3. The peripheral white blood cell count was still more than 12×109/L or less than 4×109/L after effective anti-infective treatment. Plasma C-reactive protein >2 times the upper limit of normal; Plasma procalcitonin >2 times the upper limit of normal;

4. There were severe complications or major organ complications: severe cardiovascular and cerebrovascular diseases: acute heart failure NYHA?; uncontrolled myocarditis or valvular disease; malignant arrhythmia; incident (=6 months) cardio-cerebrovascular events (myocardial infarction or stroke); previous chronic bronchitis, severe asthma, obstructive pulmonary emphysema, pulmonary fibrosis, and other diseases that require long-term oxygen therapy or affect daily activities; patients with acute renal failure (=44.2 µmol/L daily increase in serum creatinine) or chronic renal insufficiency had serum creatinine =442 µmol/L; the liver function was markedly abnormal and ALT=5×ULN; serum TBil=10×ULN or daily increase =17.1 µmol/L; signs of bleeding, PTA= 40% (or INR=1.5); severe anemia (Hb<60g/L), moderate or severe thrombocytopenia (PLT<60×109/L), and DIC; other conditions that the investigators thought might affect treatment effectiveness.

5. Unwillingness to sign informed consent forms;

6. Evidence of drug addiction within 6 months before trial entry;

7. Patients who are currently enrolled in other clinical trials and may violate this treatment regimen and observation indicators;

8. Unable or unwilling to provide informed consent or to comply with the study requirements;

9. Other serious conditions that may preclude the clinical trial.

Related Conditions & MeSH terms

• Communicable Diseases
• Infections
• Lung Injury
• Wounds and Injuries

Intervention

Drug:
• mesenchymal stem cells
Mesenchymal stem cell dose is 5×10*7/10ml and is transplanted by intravenous infusion. The cells are used once every three days and for three times

Other:
• saline
10 ml saline is used as placebo once every three days and for three times

Locations

Country	Name	City	State
China	Beijing 302 Hospital	Beijing

Sponsors (2)

Lead Sponsor	Collaborator
Cell Energy Life Sciences Group Co. LTD	Beijing 302 Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of participants with side effects in MSCs treatment groups	Investiagte the number of participants with treatment-related adverse events as assessed by CTCAE v4.0 after MSCs infusion.	48 weeks
Primary	High-resolution CT imaging	at week 2, evaluate high-resolution CT imaging changes in lung lesions and compare with baseline	2 weeks