Clinical Trials Logo

Clinical Trial Summary

In this clinical trial the Investigators aimed to assess the Adrenomedullin (AM) release in urine and plasma in preterm infants undergoing Sustained Inflation or Positive Pressure Ventilation at birth to manage respiratory failure.


Clinical Trial Description

Background and objectives: The respiratory management in the DR may play an important role in the development and prevention of lung injury. The sustained lung inflation (SI) is a promising approach to facilitate cardio-respiratory transition, but currently, although it has been shown to decrease the duration of MV, seems not to guarantee relevant benefits compared to Positive Pressure Ventilation (PPV). In order to clarify the impact of these two different approaches on lung tissues, this study measures Adrenomedullin (AM), which is a biomarker involved in lung development.

Methods: we conducted a prospective case control-study in a cohort of very low birth weight (VLBW) infants (< 1500 g) of 28+0-30+6 weeks of gestational age (GA), who received SI or PPV during stabilization in DR.

Exclusion criteria were major malformations (i.e. congenital heart disease, cerebral, lung and abdominal malformations), fetal hydrops, lack of parental consent and need for endotracheal intubation at birth.

Blood samples for AM measurement were collected at birth from the arterial umbilical cord before resuscitation maneuvers, then at 1 hour from birth and at 24 hours from birth. Moreover, urine samples were collected, in correspondence with the first urine emission while in NICU and at 24 hours of life. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03437499
Study type Interventional
Source Vittore Buzzi Children's Hospital
Contact
Status Completed
Phase N/A
Start date March 1, 2013
Completion date October 31, 2014

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05054270 - Efficacy of Lung Ultrasound in Monitoring Fluid Resuscitation in Chest Trauma Patients
Not yet recruiting NCT04470297 - Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19 Phase 2
Not yet recruiting NCT01184313 - Acute Lung Injury After Aortic Valve Surgery N/A
Not yet recruiting NCT06296173 - Open Lung Protective Extubation Following General Anesthesia N/A
Not yet recruiting NCT03661502 - Effect of Variable Volume Ventilation on Lung Compliance N/A
Recruiting NCT04296071 - Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Completed NCT04645316 - The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung N/A
Recruiting NCT02299921 - Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
Recruiting NCT05559970 - Inhalational Sedation and Mechanical Power N/A
Completed NCT03581006 - Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Trial
Recruiting NCT05228717 - Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
Recruiting NCT04372953 - Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial). N/A
Not yet recruiting NCT05363085 - The Cerebral-Respiratory Interaction in Controlled Mechanically Ventilated Neurosurgical Patients. (The CeRes-CMV Study)
Recruiting NCT02444858 - Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury Phase 1/Phase 2
Completed NCT03924206 - Hazardous Surgical Smoke: Risk Assessment and Evaluation of a New Smoke Extractor System in the Surgical Unit
Withdrawn NCT01939067 - Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP Phase 1
Recruiting NCT05401474 - Individualization Flow in Patients Treated With High Flow Nasal Therapy (iFLOW) N/A
Not yet recruiting NCT06133777 - Respiratory Variability and Postoperative Complications During Thoracic Lung Resection. N/A
Not yet recruiting NCT05381415 - Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD
Recruiting NCT04989439 - Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants